A Rare Case of Primary Cutaneous Cd4+ Small/Medium Size T-Cell Lymphoproliferative Disorder Responding to Rituximab

A Rare Case of Primary Cutaneous Cd4+ Small/Medium Size T-Cell Lymphoproliferative Disorder Responding to Rituximab Publisher

Alzahawi S¹ ; Masoomi S¹ ; Ghanadan A² ; Sadeghi Y¹ ; Daneshpazhooh M^{1, 3} ; Mahmoudi H^{1, 3}

Source: Case Reports in Dermatology Published:2025

Abstract

Introduction: Primary cutaneous CD4+ small/medium T-cell lymphoproliferative disorder is a rare lymphoproliferative disorder (PCS-TCLPD) characterized by a solitary erythematous plaque or nodule on the face, neck, or upper trunk with a favorable outcome. Very rarely, multiple plaques or masses may be seen in which precise evaluation should be performed to exclude other primary cutaneous lymphoma. Case Presentation: Here we report a rare case of recalcitrant primary cutaneous small-/ medium-sized CD4+ lymphoproliferative disorder in a 55-year-oldmale patient who responded well to rituximab injection but had recurrence after 1 year from the injections. Conclusion: Aggressive treatment is avoided in solitary lesions of PCS-TCLPD, but multiple lesions with no response to the conventional modalities may need more sophisticated management, including anti-CD20 rituximab. © 2025 The Author(s).

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Alireza Ghanadan (1)

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Style	Citing Format
MLA	Alzahawi S, et al.. "A Rare Case of Primary Cutaneous Cd4+ Small/Medium Size T-Cell Lymphoproliferative Disorder Responding to Rituximab." Case Reports in Dermatology, vol. , no. , 2025, pp. 150-156.
APA	Alzahawi S, Masoomi S, Ghanadan A, Sadeghi Y, Daneshpazhooh M, Mahmoudi H (2025). A Rare Case of Primary Cutaneous Cd4+ Small/Medium Size T-Cell Lymphoproliferative Disorder Responding to Rituximab. Case Reports in Dermatology, (), 150-156.
Chicago	Alzahawi S, Masoomi S, Ghanadan A, Sadeghi Y, Daneshpazhooh M, Mahmoudi H. "A Rare Case of Primary Cutaneous Cd4+ Small/Medium Size T-Cell Lymphoproliferative Disorder Responding to Rituximab." Case Reports in Dermatology , no. (2025): 150-156.
Harvard	Alzahawi S et al. (2025) 'A Rare Case of Primary Cutaneous Cd4+ Small/Medium Size T-Cell Lymphoproliferative Disorder Responding to Rituximab', Case Reports in Dermatology, (), pp. 150-156.
Vancouver	Alzahawi S, Masoomi S, Ghanadan A, Sadeghi Y, Daneshpazhooh M, Mahmoudi H. A Rare Case of Primary Cutaneous Cd4+ Small/Medium Size T-Cell Lymphoproliferative Disorder Responding to Rituximab. Case Reports in Dermatology. 2025;():150-156.
BibTex	@article{ author = {Alzahawi S and Masoomi S and Ghanadan A and Sadeghi Y and Daneshpazhooh M and Mahmoudi H}, title = {A Rare Case of Primary Cutaneous Cd4+ Small/Medium Size T-Cell Lymphoproliferative Disorder Responding to Rituximab}, journal = {Case Reports in Dermatology}, volume = {}, number = {}, pages = {150-156}, year = {2025} }
RIS	TY - JOUR AU - Alzahawi S AU - Masoomi S AU - Ghanadan A AU - Sadeghi Y AU - Daneshpazhooh M AU - Mahmoudi H TI - A Rare Case of Primary Cutaneous Cd4+ Small/Medium Size T-Cell Lymphoproliferative Disorder Responding to Rituximab JO - Case Reports in Dermatology VL - IS - SP - 150 EP - 156 PY - 2025 ER -

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