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Association Between Serological Responses to Two Zoonotic Ruminant Pathogens and Esophageal Squamous Cell Carcinoma Publisher Pubmed



Miller HK1 ; Stoddard RA2 ; Dawsey SM3 ; Nasrollahzadeh D4 ; Abnet CC3 ; Etemadi A3, 4 ; Kamangar F4, 5 ; Murphy G3 ; Sotoudeh M4 ; Kersh GJ1 ; Malekzadeh R4 ; Camargo MC3
Authors

Source: Vector-Borne and Zoonotic Diseases Published:2021


Abstract

Questionnaire data have linked contact with ruminants to the risk of esophageal squamous cell carcinoma (ESCC) in high-risk Asian populations. To better understand this observed association, we investigated exposure to two major zoonotic ruminant pathogens relative to ESCC risk. Using enzyme-linked immunosorbent assay, immunofluorescence assay, and Brucella microagglutination test assays, we measured immunoglobulin G anti-Coxiella burnetii and anti-Brucella spp. antibodies in patients with ESCC (n = 177) and population-based controls (n = 177) matched by age, gender, and residence area from the Golestan case-control study in Iran. We found a similarly high seroprevalence of C. burnetii in ESCC cases and controls (75% and 80%, respectively), and a similarly low seroprevalence of Brucella spp. (0% and 0.6%, respectively). While documenting a high exposure to one of two zoonotic ruminant infections, this exposure failed to explain the observed association of ruminant contact and ESCC risk in this high-risk population. © Copyright 2021, Mary Ann Liebert, Inc., publishers 2021.
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