Inhibitory Effect of Thymus Vulgaris Extract on Memory Impairment Induced by Scopolamine in Rat Publisher



Rabiei Z¹ ; Mokhtari S¹ ; Asgharzade S^{1, 2} ; Gholami M³ ; Rahnama S¹ ; Rafieiankopaei M¹
Source: Asian Pacific Journal of Tropical Biomedicine Published:2015

Abstract

Objective: To investigate the effect of Thymus vulgaris (. T. vulgaris) on learning and memory functions in scopolamine-induced memory deficit in rats. Memory enhancing activity in scopolamine-induced amnesic rats was investigated by assessing the Morris water maze and passive avoidance paradigm. Methods: A total of 42 male Wistar rats were divided into 6 equal groups as follow: control group: received water, scopolamine treated group: received scopolamine 1 mg/kg for 15 days, two scopolamine + T. vulgaris treated groups: received scopolamine and T. vulgaris extract 50 and 100 mg/kg body weight per day for 15 days, two intact groups: received T. vulgaris extract 50 and 100 mg/kg body weight per day for 15 days. Results: Administration of T. vulgaris extract significantly restored memory and learning impairments induced by scopolamine in the passive avoidance test and Morris water maze test. Conclusions: T. vulgaris extract has repairing effects on memory and behavioral disorders produced by scopolamine and may have beneficial effects in the treatment of Alzheimer's disease. © 2015 Hainan Medical University.