The Role of 1H-Mrs and [18F]Fdg Pet/Ct in Differentiating Primary Squamous Cell Carcinoma and Metastatic Hodgkin's Lymphoma in Lung: An Experimental Pilot Study Publisher



Ebrahimi M^{1, 2} ; Bitarafanrajabi A^{3, 4} ; Paymani Z⁵ ; Fardesfahani A⁶ ; Kooranifar S⁷ ; Zaresadeghi A^{1, 2} ; Raminfard S⁸ ; Nazari M⁵
Source: Iranian Journal of Nuclear Medicine Published:2024

Abstract

Introduction: Distinguishing the cellular origin of lung cancer is essential for tailored patient care. This pioneering pilot study explores the synergy of 1H-Magnetic Resonance Spectroscopy (1H-MRS) and 2-[18F] fluoro-2-deoxy-Dglucose positron emission tomography/computed tomography ([18F]FDG PET/CT) in the differentiation of primary squamous cell carcinoma (SCC) of the lung from Hodgkin's lymphoma (HL) metastases. Methods: Ethically approved, the study enrolled 21 participants with confirmed lung lesions (10 SCC, 11 HL). [18F]FDG PET/CT and 1H-MRS were conducted, and analyses were performed to assess diagnostic potential. Results: Significant differences in [18F]FDG PET/CT parameters (SUVmax BSA, SUVmax LBM, and ID%) between SCC and HL were observed. Metabolite concentrations (Cho, Lac, Cr) from 1H-MRS also exhibited distinctions. Correlations between PET values and metabolite concentrations hinted at links between glucose metabolism and molecular composition. Conclusion: This study presents an innovative approach, integrating 1H-MRS and [18F]FDG PET/CT to distinguish primary from metastatic lung lesions. The results hold promise for improving non-invasive diagnostic accuracy and guiding targeted therapies. Future research should validate these findings and explore the potential for clinical integration. Copyright © 2024 The Authors.