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Anti-Regulatory T Cell Vaccines in Immunotherapy: Focusing on Foxp3 As Target Publisher Pubmed



Mousaviniri N1 ; Naseroleslami M2 ; Hadjati J3
Authors

Source: Human Vaccines and Immunotherapeutics Published:2019


Abstract

Anti- tumor vaccination elicits imperfect immune responses against tumor cells; that is related to the presence of suppressive obstacles in the tumor microenvironment. The main members of suppressive milieu of tumor are heteroogenous groups of immune cells in which regulatory T cell is a substantial component. Tregs express different immunomodulatory molecules such as FoxP3. Transcription factor, FoxP3, is a specific intracellular marker of Treg and crucial for Treg development. Therefore it is an attractive target for cancer treatment. This article reviews some recent anti-Treg vaccine focusing on FoxP3 to ameliorate anti-tumor immune responses. Among them, fusion vaccine of FoxP3-Fc(IgG) recombinant DNA vaccine and its accordant protein vaccine represents effective results. © 2019, © 2019 Taylor & Francis Group, LLC.
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