Sciatic Nerve Regeneration by Transplantation of Menstrual Blood-Derived Stem Cells Publisher Pubmed



Farzamfar S¹ ; Naserinosar M² ; Ghanavatinejad A³ ; Vaez A² ; Zarnani AH^{4, 5} ; Salehi M⁶
Source: Molecular Biology Reports Published:2017

Abstract

This is the first study demonstrating the efficacy of menstrual blood-derived stem cell (MenSC) transplantation via a neural guidance conduit, for peripheral nerve regeneration. The synthesized poly (e-caprolactone)/Gelatin conduit, filled with collagen type I and seeded with 3 × 104 MenSCs, was implanted into a rat’s 10 mm sciatic nerve defect. The results of hot plate latency, sciatic functional index and weight-loss percentage of wet gastrocnemius muscle demonstrated that the MenSC transplantation had comparable nerve regeneration outcome to autograft, as the gold standard of nerve bridging. The transplantation of MenSCs via a synthetic conduit could ameliorate the functional recovery of sciatic nerve-injured rats which make them a potential candidate for cell therapy of peripheral nervous system disorders. © 2017, Springer Science+Business Media B.V.