Destruction Mechanisms of Ozone Over Sars-Cov-2 Publisher Pubmed



Ataeipirkooh A^{1, 2} ; Alavi A³ ; Kianirad M^{4, 5} ; Bagherzadeh K^{6, 7} ; Ghasempour A⁸ ; Pourdakan O⁸ ; Adl R¹⁰ ; Kiani SJ¹ ; Mirzaei M¹¹ ; Mehravi B^{5, 8, 9}
Source: Scientific Reports Published:2021

Abstract

In this pandemic SARS-CoV-2 crisis, any attempt to contain and eliminate the virus will also stop its spread and consequently decrease the risk of severe illness and death. While ozone treatment has been suggested as an effective disinfection process, no precise mechanism of action has been previously reported. This study aimed to further investigate the effect of ozone treatment on SARS-CoV-2. Therefore, virus collected from nasopharyngeal and oropharyngeal swab and sputum samples from symptomatic patients was exposed to ozone for different exposure times. The virus morphology and structure were monitored and analyzed through Atomic Force Microscopy (AFM), Transmission Electron Microscopy (TEM), Atomic Absorption Spectroscopy (AAS), and ATR-FTIR. The obtained results showed that ozone treatment not only unsettles the virus morphology but also alters the virus proteins’ structure and conformation through amino acid disturbance and Zn ion release from the virus non-structural proteins. These results could provide a clearer pathway for virus elimination and therapeutics preparation. © 2021, The Author(s).