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Rifampicin Resistance in Mycobacterium Tuberculosis in Iran: A Two-Centre Study Publisher



Bahraminia F1 ; Zangiabadian M2 ; Nasiri MJ3 ; Fattahi M4 ; Goudarzi M3 ; Ranjbar R5 ; Imani Fooladi AA1
Authors

Source: New Microbes and New Infections Published:2021


Abstract

Multidrug-resistant tuberculosis remains a challenge. In this study, we investigated the incidence of rifampicin (RIF) resistance in Mycobacterium tuberculosis in a large number of pulmonary specimens. A two-center study in Tehran, the capital of Iran, was performed with 6624 pulmonary samples of patients with tuberculosis (TB) who were subjected to detection of RIF-resistant TB by GeneXpert MTB/RIF assay between May 2014 and July 2018. Conventional drug susceptibility testing was performed to confirm the results. Xpert MTB/RIF identified a total of 96 positives for M. tuberculosis, of which 5 (5.3%) samples were found to be RIF-resistant TB. All RIF-resistant and sensitive isolates detected by GeneXpert were phenotypically confirmed by drug susceptibility testing. These results indicated that the Xpert MTB/RIF test can be used as a rapid diagnostic method and can potentially decrease the morbidity associated with diagnostic delay and mistreatment. © 2021 The Authors
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