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Human Colon Cancer Ht-29 Cell Death Responses to Doxorubicin and Morus Alba Leaves Flavonoid Extract Publisher Pubmed



Fallah S1, 2 ; Karimi A3 ; Panahi G3 ; Gerayesh Nejad S3 ; Fadaei R1 ; Seifi M4
Authors

Source: Cellular and Molecular Biology Published:2016


Abstract

The mechanistic basis for the biological properties of Morus alba flavonoid extract (MFE) and chemotherapy drug of doxorubicin on human colon cancer HT-29 cell line death are unknown. The effect of doxorubicin and flavonoid extract on colon cancer HT-29 cell line death and identification of APC gene expression and PARP concentration of HT-29 cell line were investigated. The results showed that flavonoid extract and doxorubicin induce a dose dependent cell death in HT-29 cell line. MFE and doxorubicin exert a cytotoxic effect on human colon cancer HT-29 cell line by probably promoting or induction of apoptosis. © 2016 by the C.M.B. Association.
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