Tehran University of Medical Sciences

Science Communicator Platform

Share By
Clinical Characteristics, Treatment, and Outcomes of Multisystem Inflammatory Syndrome in Children Associated With Covid-19: A Single-Center Study From Iran Publisher



Masoumi Asl H ; Vahedi Z ; Yousefzadegan S ; Mousavi A ; Zaremahmoudabadi R ; Shahi MV ; Kabir K ; Houjaghani H ; Behmadi R ; Mahdavynia S
Authors

Source: Journal of Comprehensive Pediatrics Published:2025


Abstract

Background: Multisystem inflammatory syndrome in children (MIS-C) is a rare but serious post-infectious inflammatory condition associated with SARS-CoV-2 infection in children. While the pathogenesis remains unclear, it is considered an immune-mediated hyper inflammatory reaction triggered by the virus. Objectives: To investigate the clinical characteristics, laboratory findings, treatments, and outcomes of MIS-C cases in an Iranian hospital. Methods: A retrospective review was conducted of 102 children meeting the World Health Organization (WHO) diagnostic criteria for MIS-C admitted to Firoozabadi Hospital in Tehran from March 2020 to February 2021. Demographic, clinical, laboratory, and outcome data were extracted from medical records. Results: Fever (96.1%) and cough (47.1%) were the most common presenting symptoms, followed by ill appearance (47.1%), nausea/vomiting (36.3%), and dyspnea (35.3%). Neurological involvement included seizures in 28.4% of cases. Lymphopenia was observed in 55.5% of patients, and abnormal blood gas levels, including hypocapnia or hypercapnia, were present in 90.6% of cases. Common treatments included antibiotics (78.0%), corticosteroids (44.0%), remdesivir (25.0%), and IVIG (13.0%). The recovery rate was 90.2%, with 26.5% of patients requiring PICU admission, and a mortality rate of 9.8%. Conclusions: This study provides epidemiological data on MIS-C in Iran, demonstrating both similarities and differences compared to previous literature. The high rate of respiratory and neurological involvement, along with distinct treatment patterns, highlights the need for further research to optimize management strategies across different healthcare settings. © 2025 Elsevier B.V., All rights reserved.
Related Docs
View other Related Docs
1. Multisystem Inflammatory Syndrome Associated With Sars-Cov-2 Infection in 45 Children: A First Report From Iran, Epidemiology and Infection (2020)
2. Hospitalization Outcomes and Laboratory Correlations in Pediatric Mis-C Patients: A Retrospective Cross-Sectional Study in Tehran, Iran, BMC Pediatrics (2026)
3. Clinical Characteristics, Laboratory Features, and Outcomes of 151 Pediatric Patients With Covid-19 and Mis-C: A Single-Center Study in the Northwest of Iran, Archives of Pediatric Infectious Diseases (2023)
Experts (# of related papers)
View all Related Experts
Shima Mahmoudi (6)
Setareh Mamishi Khanlagh (6)
Other Related Docs
4. Multisystem Inflammatory Syndrome Associated With Sars-Cov-2 Infection in Children: Update and New Insights From the Second Report of an Iranian Referral Hospital, Epidemiology and Infection (2022)
5. Evaluation of Patients Presenting With Febrile Seizures in an Iranian Referral Hospital: Emphasis on the Frequency of Meningitis and Co-Infections, BMC Pediatrics (2023)
6. Coronavirus Disease 2019 (Covid-19): A Systematic Review of 133 Children That Presented With Kawasaki-Like Multisystem Inflammatory Syndrome, Journal of Medical Virology (2021)
7. Systematic Review and Meta-Analysis on the Serological, Immunological, and Cardiac Parameters of the Multisystem Inflammatory Syndrome (Mis-C) Associated With Sars-Cov-2 Infection, Journal of Medical Virology (2023)
8. Characteristics of Children With Kawasaki Disease-Like Signs in Covid-19 Pandemic: A Systematic Review, Frontiers in Pediatrics (2021)
9. A Multicenter Retrospective Study of Clinical Features, Laboratory Characteristics, and Outcomes of 166 Hospitalized Children With Coronavirus Disease 2019 (Covid-19): A Preliminary Report From Iranian Network for Research in Viral Diseases (Inrvd), Pediatric Pulmonology (2022)
10. Covid-19 Infection in Children With Underlying Malignancies in Iran, Journal of Basic and Clinical Physiology and Pharmacology (2022)
11. Covid-19, an Early Investigation From Exposure to Treatment Outcomes in Tehran, Iran, Journal of Research in Medical Sciences (2021)
12. Methylprednisolone Pulses As an Initial Treatment in Hyperinflammatory Syndrome After Covid-19 in Children: Evaluation of Laboratory Data, Serial Echocardiography and Outcome: A Case Series, Intensive Care Medicine Experimental (2022)
13. Covid-19 Clinical Manifestations and Treatment Strategies Among Solid-Organ Recipients: A Systematic Review of Cases, Transplant Infectious Disease (2020)
14. Radiologic Analysis of Ct Imaging Patterns and Clinical Correlations in Hospitalized Pediatric Covid-19 Patients, Frontiers in Radiology (2025)
15. Comparison of Clinical, Para-Clinical and Laboratory Findings in Survived and Deceased Patients With Covid-19: Diagnostic Role of Inflammatory Indications in Determining the Severity of Illness, BMC Infectious Diseases (2020)
16. Children With Sars-Cov-2 Infection During the Novel Coronaviral Disease (Covid-19) Outbreak in Iran: An Alarming Concern for Severity and Mortality of the Disease, BMC Infectious Diseases (2022)
17. Understanding the Clinical and Demographic Characteristics of Second Coronavirus Spike in 192 Patients in Tehran, Iran: A Retrospective Study, PloS one (2021)
18. The Comparison of Clinical, Laboratory, and Radiological Findings in Immunocompromised and Immunocompetent Patients With Covid-19: A Case-Control Study, Immunity# Inflammation and Disease (2023)
19. Acute Necrotizing Encephalopathy in Adult Patients With Covid-19: A Systematic Review of Case Reports and Case Series, Journal of Clinical Neurology (Korea) (2023)
20. Characteristics and Outcomes of Covid-19 Patients During the Ba.5 Omicron Wave in Tehran, Iran: A Prospective Observational Study, BMC Infectious Diseases (2023)