Prevalence and Clinico-Pathologic Profiles of Nonodontogenic Cysts of the Oral and Maxillofacial Region: A Multicentre Study Publisher

Summary: Ever wondered about nonodontogenic cysts? A study found 1.02% of 183,132 cases were NOCs, mostly in soft tissue. Age ranged from 1 to 96 years. What does this mean for diagnosis? #OralHealth #DentalResearch

Chantarangsu S ; Kulthanaamondhita P ; Dhanuthai K ; Sappayatosok K ; Klanrit P ; Chamusri N ; Aminishakib P ; Hosseini SM ; Singh R ; Uddin J ; Darling M
Source: International Journal of Dentistry Published:2025

Abstract

Objectives: To determine the prevalences, demographic, and pathologic profiles of patients diagnosed with nonodontogenic cysts (NOCs) in the oral and maxillofacial regions. Materials and Methods: Biopsy records from the participating institutions from 2000 to 2024 were studied for lesions diagnosed in the NOC category. Demographic profiles, the locations, and pathologic diagnoses were collected. Data were analyzed by using IBM SPSS Statistics version 29.0. Results: A total of 183,132 cases were obtained and 1864 cases (1.02%) were diagnosed as NOCs. The age of the patient ranged from 1 to 96 years with mean ± SD = 49.03 ± 18.43 years. The overall male-to-female ratio was 1.08:1. The majority of the lesions were encountered in the soft tissue. The most prevalent NOC was nasopalatine duct cyst followed by mucus retention cysts and nasolabial cysts. Conclusions: This study is the largest study on NOCs from Southeast Asia, the Middle East, and North America. The frequency of NOCs found in this studied population is somewhat different from those reported in previous studies. This study offers a valuable database for clinicians to facilitate the clinical differential diagnoses along with for the pathologists in rendering the final diagnosis. Copyright © 2025 Soranun Chantarangsu et al. International Journal of Dentistry published by John Wiley & Sons Ltd.