Understanding the Signaling Pathway As a New Strategy for Bum Management and Treatment Based on Stem Cell Therapy Publisher



Mohammadi M¹ ; Moayeri A² ; Ghaderi O³ ; Mohammadi HR⁴ ; Rostamzadeh A⁵
Source: Research Journal of Medical Sciences Published:2016

Abstract

Bum injury has been reported to be an important cause of morbidity and mortality in many countries which leads to a loss of integrity of the skin which protects us from water loss, temperature change, radiation, trauma and infection. The main sources of stem cells that might be used for repair and regeneration of injured skin tissue are Embryonic Stem Cells (ESCs) and adult stem cells. ESCs have a great capacity for self-renewal and pluripotency but their clinical applications are limited because of the political and ethical considerations. Also, ESCs themselves are less suitable for tissue grafting; they do provide the potential to augment physiological healing processes via paracrine mechanisms. Stem cells allows for the possibility of restoring lost or damaged tissue, while their ability to modulation of immune system the wound bed from afar suggests that their clinical applications need not be restricted to direct tissue formation. The clinical utility of stem cells has been demonstrated across dozens of clinical trials in chronic wound therapy; thus, it promotes normal interactions between cell assemblies during the regeneration of bum wounds which prevents the formation of cicatrix or the deformation of tissues. Furthermore, Induced Pluripotent Stem Cells (iPSCs) derived fibroblasts may be an increased production of extracellular matrix proteins that could also increase the rate of wound healing as well as provide opportunities for eventually generating these structures without the risk of immune rejection. © Medwell Journals, 2016.