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Prostate Cancer and Noncoding Rnas: A Focus on Mirnas, Lncrnas, and Circrnas Publisher



Nazari A1 ; Osati P2 ; Fakhr SS3 ; Akhoundattar M4 ; Far NP5 ; Rajabi M6 ; Seyed Karimi M7 ; Ebrahimi N8 ; Hajifatahaliha M9 ; Aref AR10, 11
Authors

Source: Prostate Cancer: Molecular Events and Therapeutic Modalities Published:2024


Abstract

Noncoding RNAs (ncRNAs) are a class of regulatory transcripts that play important functions in the pathogenesis of several cancer types, including prostate cancer (PCa). Within the framework of prostate cancer, non-coding RNAs have the capacity to function as either oncogenic or tumor-suppressive agents. ncRNAs have the potential to participate in the prostate cancer progression by influencing the signaling of the androgen receptor (AR), the degradation process of AR via ubiquitin-proteasome pathways, or other critical signaling pathways. This chapter provides a detailed review of the involvement of ncRNAs in the evolutionary processes of PCa, with a particular emphasis on their significance in the development of innovative biomarker profiles and targets for cancer treatment. © The Author(s). All rights reserved.
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