Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Adherence to Combined Healthy Lifestyle and Odds of Metabolic Syndrome in Iranian Adults: The Persian Dena Cohort Study Publisher Pubmed

Summary: Live healthy, dodge MetS? Study (n=2971) finds top HLS (BMI, PAL, HEI-2020) cuts odds 81% for syndrome, components. Research urges lifestyle tweaks for Iranians. Score your habits? #MetabolicSyndrome #HealthyLifestyle

Jowshan MR1 ; Pourjavid A2 ; Amirkhizi F3 ; Hosseini MH1 ; Zolghadrpour MA1 ; Hamedishahraki S4 ; Motlagh AH5 ; Asghari S1
Authors

Source: Scientific Reports Published:2025


Abstract

The relationship between lifestyle choices and health outcomes has received significant scholarly attention. Research indicates that factors such as obesity, insufficient physical activity, tobacco use, and poor dietary habits may elevate the odds of developing metabolic disorders. This study aimed to investigate the association between the combined healthy lifestyle score (HLS) and the odds of metabolic syndrome (MetS) and its associated components in a population of apparently healthy adults. This cross-sectional study utilized data from the Dena PERSIAN cohort, which comprised 2,971 healthy adults. Participants’ combined HLS were evaluated using validated questionnaires that assessed body mass index (BMI), physical activity level (PAL), smoking status, and dietary quality. The evaluation of dietary nutritional quality was conducted using the most recent version of the Healthy Eating Index (HEI), known as HEI-2020. The combined HLS was measured on a scale ranging from zero, indicating an unhealthy lifestyle, to four, representing the healthiest lifestyle. Individuals with the highest combined HLS score had 81% lower odds of having MetS compared to those with the lowest score (OR: 0.19; 95% CI: 0.11–0.33). Higher combined HLS scores were significantly associated with decreased odds of abdominal adiposity (OR: 0.11; 95% CI: 0.07–0.18), abnormal glucose homeostasis (OR: 0.55; 95% CI: 0.35–0.86), elevated serum triglycerides (OR: 0.41; 95% CI: 0.26–0.67), and low high-density lipoprotein cholesterol (HDL-C) levels (OR: 0.39; 95% CI: 0.24–0.65) after adjusting for sex, age, education level, and marital status (P < 0.05). The findings indicated a significant association between adherence to a combined HLS and a decreased odds of developing MetS and its associated components among Iranian adults. © The Author(s) 2025.
Related Docs
View other Related Docs
1. The Higher Adherence to Healthy Lifestyle Factors Is Associated With a Decreased Risk of Metabolic Syndrome in Iranian Adults, Nutrition Bulletin (2022)
2. Association Between Healthy Eating Index-2015 Scores and Metabolic Syndrome Among Iranian Women: A Cross-Sectional Study, BMC Women's Health (2024)
3. Combined Healthy Lifestyle Score and Odds of Rheumatoid Arthritis in Iranian Adults: A Nested Case-Control From Persian Dena Cohort Study (Pdcs), BMJ Open (2025)
Experts (# of related papers)
View all Related Experts
Kurosh Djafarian (6)
Sakineh Shab-Bidar (6)
Adherence to Combined Healthy Lifestyle and Odds of Metabolic Syndrome in Iranian Adults: The Persian Dena Cohort Study
Other Related Docs
4. Association of Main Meal Quality Index With the Odds of Metabolic Syndrome in Iranian Adults: A Cross-Sectional Study, BMC Nutrition (2023)
5. Association of Dietary and Lifestyle Inflammation Score With Metabolic Syndrome in a Sample of Iranian Adults, Frontiers in Nutrition (2021)
6. The Association of Healthy Lifestyle Score and Risk of Non-Alcoholic Fatty Liver Disease, BMC Public Health (2023)
7. The Higher Adherence to a Healthy Lifestyle Score Is Associated With a Decreased Risk of Type 2 Diabetes in Iranian Adults, BMC Endocrine Disorders (2022)
8. Healthy Eating Index and Anthropometric Status in Young Children: A Cross-Sectional Study, Clinical Nutrition ESPEN (2021)
9. How Is Healthy Eating Index-2015 Related to Risk Factors for Cardiovascular Disease in Patients With Type 2 Diabetes, Frontiers in Nutrition (2023)
10. Adherence to Dietary Approaches to Stop Hypertension (Dash) and Mediterranean Dietary Patterns in Relation to Cardiovascular Risk Factors in Older Adults, Clinical Nutrition ESPEN (2020)
11. Association of Healthy Eating Index and Anthropometric Indices Among Primary School Girls in Southeast of Iran: A Cross-Sectional Study, BMC Nutrition (2024)
12. Association of Nightly Fasting Duration, Meal Timing and Frequency With the Metabolic Syndrome Among Iranian Adults, British Journal of Nutrition (2023)
13. The Association Between the Dietary Behavior, Diet Quality, and Lifestyle Scores With Anthropometric Indices and Happiness Levels Among University Students, BMC Nutrition (2024)
14. Interaction Between Cetp Taq1b Polymorphism and Hei, Dqi and Dpi on Metabolic Biomarkers in Patients With Type 2 Diabetes, Journal of Human Nutrition and Dietetics (2022)
15. The Association Between Plant-Based Diet Indices and Metabolic Syndrome in Iranian Older Adults, Nutrition and Health (2021)
16. Cardiometabolic Risk Factor Clusters in Older Adults Using Latent Class Analysis on the Bushehr Elderly Health Program, Scientific Reports (2024)
17. Association of Dietary Acid Load With Cardiovascular Risk Factors and the Prevalence of Metabolic Syndrome in Iranian Women: A Cross-Sectional Study, Nutrition (2019)
18. The Association Between Healthy Lifestyle Score With Cardiorespiratory Fitness and Muscle Strength, International Journal of Clinical Practice (2020)
19. The Association Between the Nordic-Style Diet Score and Metabolic Syndrome and Obesity in Tehranian Adults, Nutrition Today (2021)
20. Validity and Reproducibility of the Persian Cohort Food Frequency Questionnaire: Assessment of Major Dietary Patterns, Nutrition Journal (2024)