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Surgery-Induced Weight Loss and Changes in Hormonally Active Fibroblast Growth Factors: A Systematic Review and Meta-Analysis Publisher Pubmed



Hosseinzadeh A1 ; Roever L2 ; Alizadeh S3
Authors

Source: Obesity Surgery Published:2020


Abstract

This systematic review and meta-analysis was performed to investigate the possible changes of FGF-19 and FGF-21 after bariatric surgery (BS). Electronic databases including PubMed and Scopus were systematically searched up to February 2020 to identify pertinent studies. A total of 25 different studies were included. The overall pooled analysis identified that BS caused a significant increase in FGF-19, but had no significant effect on FGF-21. For FGF-19, this finding was supported in the subgroup analyses. For FGF-21, Roux-en-Y gastric bypass (RYGB) surgery significantly increased FGF-21 levels, whereas, in studies with follow-up duration ≥ 1 year, FGF-21 levels decreased significantly. BS reduces circulating concentration of FGF-19, but might increase FGF-21 after RYGB or decrease FGF-21 after ≥ 1 year. © 2020, Springer Science+Business Media, LLC, part of Springer Nature.
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