Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
New Epigenetic Players in Stroke Pathogenesis: From Non-Coding Rnas to Exosomal Non-Coding Rnas Publisher Pubmed



Mahjoubintehran M1, 2 ; Rezaei S1, 2 ; Jesmani A3 ; Birang N4 ; Morshedi K5 ; Khanbabaei H6 ; Khan H7 ; Piranviseh A8 ; Nejati M9 ; Aschner M10 ; Mirzaei H11
Authors

Source: Biomedicine and Pharmacotherapy Published:2021


Abstract

Non-coding RNAs (ncRNAs) have critical role in the pathophysiology as well as recovery after ischemic stroke. ncRNAs, particularly microRNAs, and the long non-coding RNAs (lncRNAs) are critical for angiogenesis and neuroprotection, and they have been suggested to be therapeutic, diagnostic and prognostic tools in cerebrovascular diseases, including stroke. Moreover, exosomes have been considered as nanocarriers capable of transferring various cargos, such as lncRNAs and miRNAs to recipient cells, with prominent inter-cellular roles in the mediation of neuro-restorative events following strokes and neural injuries. In this review, we summarize the pathogenic role of ncRNAs and exosomal ncRNAs in the stroke. © 2021 The Authors
Other Related Docs
4. Microrna Biogenesis and Function, Synthesis Lectures on Biomedical Engineering (2022)
14. Micrornas and Exosomes: Cardiac Stem Cells in Heart Diseases, Pathology Research and Practice (2022)
17. Targeting Epigenetics in Cancer: Therapeutic Potential of Flavonoids, Critical Reviews in Food Science and Nutrition (2021)