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Depression Is Associated With Downregulation of Ips-1 in Chronic Hbv-Infected Patients in a Sex-Dependent Manner Publisher Pubmed



Safariarababadi M1 ; Modarressi MH1, 2 ; Sheikhfatholahi M3, 4 ; Khaleghinia M5 ; Arababadi MK3, 6
Authors

Source: NeuroImmunoModulation Published:2021


Abstract

Background: Depression and anxiety can modulate immune-related molecule expressions. The chronic HBV-infected (CHB) patients suffer from inappropriate immune responses. Additionally, psychological disorders are prevalent among the patients. Thus, depression and anxiety may alter immune-related molecule expression. This study aimed to examine IPS-1 and RIP1 mRNA levels in CHB patients suffering from various degrees of anxiety and depression. Methods: Sixty patients with CHB participated in this research and completed standard questionnaires to evaluate depression and anxiety. The expression levels of IPS-1 and RIP1 were examined using real-time PCR techniques. Results: The result revealed that although the expression of IPS-1 and RIP1 did not change in the CHB patients with various ranges of depression and anxiety, IPS-1 was significantly decreased in the male CHB patients who suffered from mild, moderate, and severe depression when compared to the patients with no depression. Conclusion: So, it was hypothesized that depression may be associated with alteration in the expression of IPS-1 in a sex-dependent manner. In other words, it appears that the male CHB patients are at risk of depression-related alteration in immune-related gene expression. © 2021 S. Karger AG. All rights reserved.
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