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Adult Height and Risk of Gastric Cancer: A Pooled Analysis Within the Stomach Cancer Pooling Project Publisher Pubmed



Giraldi L1 ; Stojanovic J1, 2, 3 ; Arzani D1 ; Persiani R4, 5 ; Hu J6 ; Johnson KC7 ; Zhang ZF8 ; Ferraroni M9 ; Palli D10 ; Yu GP11 ; La Vecchia C9 ; Pelucchi C9 ; Lunet N12, 13 ; Ferro A13 Show All Authors
Authors
  1. Giraldi L1
  2. Stojanovic J1, 2, 3
  3. Arzani D1
  4. Persiani R4, 5
  5. Hu J6
  6. Johnson KC7
  7. Zhang ZF8
  8. Ferraroni M9
  9. Palli D10
  10. Yu GP11
  11. La Vecchia C9
  12. Pelucchi C9
  13. Lunet N12, 13
  14. Ferro A13
  15. Malekzadeh R14
  16. Muscat J15
  17. Zaridze D16
  18. Maximovich D16
  19. Aragones N17, 18
  20. Martin V18, 19, 30
  21. Vioque J18, 20
  22. Navarretemunoz EM18, 20
  23. Pakseresht M14, 21, 22
  24. Negri E23
  25. Rota M9
  26. Pourfarzi F14, 24
  27. Mu L25
  28. Kurtz RC26
  29. Lagiou A27
  30. Lagiou P28, 29
  31. Pastorino R5
  32. Boccia S1, 5

Source: European Journal of Cancer Prevention Published:2023


Abstract

Background The association between height and risk of gastric cancer has been studied in several epidemiological studies with contrasting results. The aim of this study is to examine the association between adult height and gastric cancer within a large pooled analysis of case-control studies members of the Stomach cancer Pooling (StoP) Project consortium. Methods Data from 18 studies members of the StoP consortium were collected and analyzed. A multivariable logistic regression model was used to estimate the study-specific odds ratios (ORs) and 95% confidence intervals (CIs) for the association between 10-cm increase in height and risk of gastric cancer. Age, sex, tobacco smoking, alcohol consumption, social class, geographical area and Helicobacter pylori (H. pylori) status were included in the regression model. Resulting estimates were then pooled with random-effect model. Analyses were conducted overall and in strata of selected variables. Results A total of 7562 cases and 19 033 controls were included in the analysis. The pooled OR was 0.96 (95% CI 0.87-1.05). A sensitivity analysis was performed restricting the results to the studies with information on H. pylori status, resulting in an OR of 0.97 (95% CI 0.79-1.20). Conclusion Our study does not support a strong and consistent association between adult height and gastric cancer. © 2023 Lippincott Williams and Wilkins. All rights reserved.
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7. The Stomach Cancer Pooling (Stop) Project: Study Design and Presentation, European Journal of Cancer Prevention (2015)