Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Effect of Processing/Formulation Parameters on Particle Size of Nanoemulsions Containing Ibuprofen - an Artificial Neural Networks Study Publisher



Hanafi A1 ; Amani A2, 3
Authors

Source: Pharmaceutical Sciences Published:2021


Abstract

Background: Nanoemulsions are colloidal transparent systems for the delivery of hydrophobic drugs. This study aimed to determine the effect of parameters affecting particle size of a nanoemulsion containing ibuprofen using artificial neural networks (ANNs). Methods: Nanoemulsion samples with different values of independent variables, namely, concentration of ethanol, ibuprofen and Tween 80 as well as exposure (homogenization) time were prepared and their particle size was measured using dynamic light scattering (DLS). The data were then modelled by ANNs. Results: From the results, increasing the exposure time had a positive effect on reducing droplet size. The effect of concentration of ethanol and Tween 80 on droplet size depended on the amount of ibuprofen. Our results demonstrate that ibuprofen concentration also had a reverse relation with the size of the nanoemulsions. Conclusion: It was concluded that to obtain minimum particle size, exposure (homogenization) time should be maximized. © 2021 The Author(s).
Related Docs
View other Related Docs
1. Use of Artificial Neural Networks for Analysis of the Factors Affecting Particle Size in Mebudipine Nanoemulsion, Journal of Biomolecular Structure and Dynamics (2019)
2. Size Control in the Nanoprecipitation Process of Stable Iodine (127I) Using Microchannel Reactor—Optimization by Artificial Neural Networks, AAPS PharmSciTech (2015)
3. Concurrent Study of Stability and Cytotoxicity of a Novel Nanoemulsion System–An Artificial Neural Networks Approach, Pharmaceutical Development and Technology (2017)
Experts (# of related papers)
View all Related Experts
Rassoul Dinarvand (3)
Alireza Firooz (1)
Other Related Docs
4. Introducing Humidity and Temperature As Important Parameters Determining the Size of Electrosprayed Chitosan Nanoparticles, Nanomedicine Research Journal (2021)
5. Size, Loading Efficiency, and Cytotoxicity of Albumin-Loaded Chitosan Nanoparticles: An Artificial Neural Networks Study, Journal of Pharmaceutical Sciences (2017)
6. Ratio of Drug/Carrier As Dominant Factor in Determining Size of Doxorubicin-Loaded Beta-1,3- Glucan Nanoparticles: A Study Using Artificial Neural Networks, Nanomedicine Research Journal (2020)
7. Optimizing Microfluidic Preparation Parameters of Nanosuspension to Evaluate Stability in Nanoprecipitation of Stable-Iodine (127I), SN Applied Sciences (2019)
8. The Significance of Artificial Intelligence in Drug Delivery System Design, Advanced Drug Delivery Reviews (2019)
9. Tretinoin Loaded Nanoemulsion for Acne Vulgaris: Fabrication, Physicochemical and Clinical Efficacy Assessments, Skin Pharmacology and Physiology (2018)
10. Molecular Dynamics Simulation of Self-Assembly in a Nanoemulsion System, Chemical Papers (2020)
11. Size Prediction of Drug-Loaded Polymeric (Plga) Microparticles Prepared by Microfluidics, Journal of Drug Delivery Science and Technology (2024)
12. Application of Electrospray in Preparing Solid Lipid Nanoparticles and Optimization of Nanoparticles Using Artificial Neural Networks, Avicenna Journal of Medical Biotechnology (2020)
13. Effect of Various Parameters on Encapsulation Efficiency of Mpeg-Plga Nanoparticles: Artificial Neural Network, Biointerface Research in Applied Chemistry (2018)
14. Optimization of Paclitaxel-Loaded Poly (D,L-Lactide-Co-Glycolide-N-P-Maleimido Benzoic Hydrazide) Nanoparticles Size Using Artificial Neural Networks, Pharmaceutical Development and Technology (2015)
15. St8 Micellar/Niosomal Vesicular Nanoformulation for Delivery of Naproxen in Cancer Cells: Physicochemical Characterization and Cytotoxicity Evaluation, Journal of Molecular Structure (2020)
16. Artificial Intelligence in Nanotechnology for Treatment of Diseases, Journal of Drug Targeting (2024)
17. Molecular Dynamics Simulation of Sirna Loading Into a Nanoemulsion As a Potential Carrier, Journal of Molecular Modeling (2020)
18. Preparation, Statistical Optimization and in Vitro Characterization of Solid Lipid Nanoparticles As a Potential Vehicle for Transdermal Delivery of Tramadol Hydrochloride As a Hydrophilic Compound, Nanomedicine Research Journal (2020)
19. Efficacy of Nano- and Microemulsion-Based Topical Gels in Delivery of Ibuprofen: An in Vivo Study, Journal of Microencapsulation (2017)
20. Preparation and Optimisation of Solid Lipid Nanoparticles of Rivaroxaban Using Artificial Neural Networks and Response Surface Method, Journal of Microencapsulation (2025)