Prediction of Remission in Cushing’S Disease Using Artificial Intelligence: A Systematic Review and Meta-Analysis Publisher Pubmed



Alvani MS ; Mohammadzadeh I ; Hajikarimloo B ; Sanikommu S ; Mortezaei A ; Eini P ; Mohammadzadeh S ; Habibi MA ; Mousavinejad SA ; Himic V ; Di Ieva A ; Komotar RJ
Source: Neurosurgical Review Published:2026

Abstract

Predicting remission in Cushing’s disease (CD) following transsphenoidal surgery (TSS) is crucial for improving treatment strategies and patient outcomes. This systematic review and meta-analysis aimed to evaluate the application of Artificial Intelligence (AI) algorithms in forecasting remission outcomes, integrating diverse clinical, biochemical, and imaging data to enhance predictive accuracy. A comprehensive search was conducted across PubMed, Web of Science, Embase, Scopus, and Google Scholar databases up to December 2024, adhering to PRISMA guidelines. Out of 1,571 records identified, five studies involving 1,938 patients met the inclusion criteria. The pooled sensitivity and specificity of Machine learning (ML) models were 0.93 [95% CI: 0.65–0.99] and 0.78 [95% CI: 0.50–0.93], respectively, with the diagnostic score was 3.8 [95% CI: 0.86–6.74] and diagnostic odds ratio (DOR) of 44.79 [95% CI: 2.37–846.66]. The positive diagnostic likelihood ratio (DLR) was 4.23 [95% CI: 1.39–12.86], while the negative DLR was 0.09 [95% CI: 0.01–0.67]. The area under the curve (AUC) was 0.91. These results underscore the significant potential of AI algorithms in enhancing clinical decision-making and improving the prediction of remission in CD. However, methodological heterogeneity and the lack of external validation across studies call for standardized approaches to ensure broader applicability and reliability of these models in clinical settings. © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2026.