Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Comparing Effects of Different Routes of Heparin Administration on the Serum Biomarkers of Thrombosis Publisher Pubmed



Izadpanah M1 ; Mohammadi M2 ; Khalili H3 ; Faramarzi MA4
Authors

Source: Journal of Comparative Effectiveness Research Published:2016


Abstract

Background: Association between thrombosis pathogenesis and inflammatory conditions has been reported. Also inflammatory biomarkers have been proposed for prediction of thrombosis events. Objectives: Effects of different methods of heparin administration (subcutaneous vs continuous infusion) as thromboprophylaxis on the biomarkers of thrombosis have been evaluated. Methods: Serum levels of hsCRP, IL-10 and P-selectin as the biomarkers of thrombosis were measured at baseline, days 3 and 7 during the patients' hospitalization period. Results: Changes in the serum levels of thrombosis biomarkers (hsCRP, IL-10 and P-selectin) were comparable between the subcutaneous and continuous infusion groups. Conclusion: Both subcutaneous injection and continuous infusion of heparin as thromboprophylaxis showed same effects on the thrombosis biomarkers. © 2016 Future Medicine Ltd.
Related Docs
View other Related Docs
1. Comparing Safety of Heparin As Continuous Intravenous Infusion and Multiple Subcutaneous Injections, Journal of Comparative Effectiveness Research (2016)
2. Heparin and Related Drugs for Venous Thromboembolism Prophylaxis: Subcutaneous or Intravenous Continuous Infusion?, Journal of Comparative Effectiveness Research (2015)
3. The Effect of High-Dose Vitamin D3 on Soluble P-Selectin and Hs-Crp Level in Patients With Venous Thromboembolism, Clinical and Applied Thrombosis/Hemostasis (2016)
Experts (# of related papers)
View all Related Experts
Hossein Khalili (3)
Mohammad Vaezi (2)
Other Related Docs
4. Differentiating the Effects of Prophylactic Unfractionated Heparin Infusion by Rotational Thromboelastometry in Sepsis, Point of Care (2018)
5. Thromboprophylaxis Challenge After Pancreas Transplantation: A Literature Review, International Journal of Organ Transplantation Medicine (2022)
6. Efficacy and Safety of a Doac Compared to Unfractionated Heparin and a Low Molecular Weight Heparin in the Prevention of Thromboembolism in Hematopoietic Stem Cell Transplant Recipients, Iranian Journal of Pharmaceutical Research (2024)
7. Prognostic Value of Inflammatory Markers Including Neutrophil to Lymphocyte Ratio, Platelet to Lymphocyte Ratio, Mean Platelet Volume, Platelet Distribution Width, and Red Blood Cell Distribution Width in Viral Hepatitis: A Systematic Review and Meta-Analysis, Journal of Clinical Virology Plus (2025)
8. Anti-Inflammatory Effects of Heparin and Its Derivatives: A Systematic Review, Advances in Pharmacological Sciences (2015)
9. Reevaluating the Role of Heparin During Mechanical Thrombectomy for Acute Ischemic Stroke: Increased Risks Without Functional Benefit, Clinical Neurology and Neurosurgery (2024)
10. Investigating the Refractory Platelet Transfusion: Understanding the Underlying Factors, Diagnosis, and Effective Treatment Strategies, Iranian Journal of Blood and Cancer (2025)
11. Fcrn Inhibitors in Immune Thrombocytopenia: A Comprehensive Review of Therapeutic Advances and Clinical Outcomes, Cytokine (2025)
12. Covid-19 Associated Thrombotic Thrombocytopenic Purpura (Ttp); a Case Series and Mini-Review, International Immunopharmacology (2021)
13. Atorvastatin Versus Placebo in Patients With Covid-19 in Intensive Care: Randomized Controlled Trial, The BMJ (2022)
14. Slow Versus Fast Subcutaneous Heparin Injections for Prevention of Bruising and Site Pain Intensity, Cochrane Database of Systematic Reviews (2017)
15. Efficacy and Safety of Syk and Btk Inhibitors in Immune Thrombocytopenia: A Comprehensive Review of Emerging Evidence, Mediators of Inflammation (2025)
16. Abbreviated Dual Antiplatelet Therapy in Patients Undergoing Percutaneous Coronary Intervention: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, BMC Cardiovascular Disorders (2025)
17. Clinical Features and Risk Factors of Relapse and Mortality in Thrombotic Thrombocytopenic Purpura Patients: A Seven-Year Experience, International Journal of Hematology-Oncology and Stem Cell Research (2023)
18. Aspirin Is As Effective As Low Molecular Weight Heparins in Preventing Symptomatic Venous Thromboembolism Following Arthroscopic Anterior Cruciate Ligament Reconstruction, BMC Musculoskeletal Disorders (2024)
19. Multi-Omics Insights Into Autoimmune Thrombocytopenic Purpura, Comprehensive Hematology and Stem Cell Research: Volume 1-5 (2024)
20. Inflammation in Venous Thromboembolism: Cause or Consequence?, International Immunopharmacology (2015)