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Synthesis of Novel 5-Arylidene (Thio)Barbituric Acid and Evaluation of Their Urease Inhibitory Activity Publisher



Vosooghi M1 ; Farzipour S1 ; Saeedi M2, 3 ; Shareh NB1 ; Mahdavi M1 ; Mahernia S1 ; Foroumadi A1 ; Amanlou M1 ; Shafiee A1
Authors

Source: Journal of the Iranian Chemical Society Published:2015


Abstract

Abstract A simple and practical method is described for the synthesis of novel 5-arylidene derivatives of barbituric and thiobarbituric acid. 2-Formylbenzoic acids reacted easily with (thio)barbituric acids in the presence of p-toluenesulfonic acid (p-TsOH) in MeOH/EtOH to obtain the title compound in good yields. Then, their urease inhibitory activity were evaluated in vitro and compared with hydroxyurea as the reference drug. © 2015 Iranian Chemical Society.
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