Direct Oral Anticoagulants for Treatment of Venous Thrombosis: Illustrated Review of Appropriate Use Publisher



Khairani CD¹ ; Bejjani A¹ ; Assi A¹ ; Porio N¹ ; Talasaz AH^{2, 3} ; Piazza G^{1, 4} ; Cushman M⁵ ; Bikdeli B^{1, 4, 6, 7}
Source: Research and Practice in Thrombosis and Haemostasis Published:2024

Abstract

Direct oral anticoagulants (DOACs) have become the preferred option for treatment of venous thromboembolism due to their favorable profile compared with other agents such as vitamin K antagonists or low-molecular-weight heparin. However, findings from randomized controlled trials suggest efficacy and/or safety concerns with DOAC use in some clinical contexts. This illustrated review will summarize indications where DOACs have proven efficacy and safety, situations where they fall short, and situations where uncertainty remains compared with other treatments for venous thromboembolism. © 2024 The Author(s)