Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Comparative Study of the Effect of Various Bariatric Surgery Methods on Liver Enzymes and Grading of Nonalcoholic Fatty Liver Based on Ultrasound Scans in Children and Adults Publisher



Yousefi A1 ; Safari F2 ; Pazouki A3 ; Pourzahabi Z4 ; Riazi S3 ; Talebi A5
Authors

Source: World Journal of Laparoscopic Surgery Published:2022


Abstract

Introduction: Bariatric surgery is one of the most effective treatments for patients with morbid obesity. Rapid weight loss can accelerate thprocess of fibrosis, and weight loss alone can improve the process of steatohepatitis. The conflict has confused the effect of these surgeries othe severity of the fatty liver disease. This retrospective study aimed to compare the effects of different types of bariatric surgery on the gradinand severity of the nonalcoholic fatty liver disease (NAFLD). Materials and methods: Using the National Obesity Surgery Database, data were extracted from 900 patients with a body mass index (BMI) above 35 who underwent sleeve, classic bypass, or mini-bypass surgery or who did not undergo surgery for any reason. Body mass index, aspartate transaminase (AST), alanine transaminase (ALT), NAFLD fibrosis score, and liver ultrasound were evaluated before and after surgery in four different groups. Results: All three surgical procedures effectively reduced BMI. Among the various surgical procedures, the rate of BMI reduction was significantly higher in the mini-gastric bypass procedure than in the other two methods. The reduction of AST and ALT was significant in all three surgical methods compared to the nonsurgical group, with the highest reduction in sleeve surgery. Fatty liver based on ultrasound in the nonsurgical group in the second time got worse but improved significantly in all the operated groups, and all these changes including the development of fatty liver in the nonsurgical group and its improvement in the operated groups were significant (p <0.05) and NAFLD fibrosis score (NFS) decreased in all groups. This reduction was small and insignificant for the nonsurgical group while it was significant in the three operated groups. © The Author(s). 2022.
Related Docs
View other Related Docs
1. Changes in Serum Albumin and Liver Enzymes Following Three Different Types of Bariatric Surgery: Six-Month Follow-Up. a Retrospective Cohort Study, Sao Paulo Medical Journal (2021)
2. The Effect of Laparoscopic Sleeve Gastrectomy and Gastric Bypass Surgery on Non-Alcoholic Steatohepatitis in Iranian Patients With Obesity, Middle East Journal of Digestive Diseases (2021)
3. Synbiotic Supplementation in Lean Patients With Non-Alcoholic Fatty Liver Disease: A Pilot, Randomised, Double-Blind, Placebo-Controlled, Clinical Trial, British Journal of Nutrition (2017)
Experts (# of related papers)
View all Related Experts
Hossein Poustchi (3)
Reza Malekzadeh (2)
Other Related Docs
4. Which One Is Better for Non-Alcoholic Fatty Liver Disease, the Roux-En-Y Gastric Bypass or One Anastomosis Gastric Bypass? a Paired Liver Biopsy Report, Obesity Medicine (2020)
5. Association Between Melatonin Value and Interleukins-1B,-18, And-33 Levels in Patients With Different Stages of Non-Alcoholic Fatty Liver Disease, Middle East Journal of Digestive Diseases (2022)
6. Excessive Weight Loss After Bariatric Surgery: A Prediction Model Retrospective Cohort Study, Updates in Surgery (2022)
7. Nonalcoholic Fatty Liver: The Association With Metabolic Abnormalities, Body Mass Index and Central Obesity - a Population-Based Study, Metabolic Syndrome and Related Disorders (2015)
8. Prediction of Nonalcoholic Fatty Liver Disease Via a Novel Panel of Serum Adipokines, Medicine (United States) (2016)
9. Influence of Gastric Bypass Surgery on Resting Energy Expenditure, Body Composition, Physical Activity, and Thyroid Hormones in Morbidly Obese Patients, Diabetes# Metabolic Syndrome and Obesity (2018)
10. Parathyroid Hormone Levels May Predict Nonalcoholic Steatohepatitis in Morbidly Obese Patients, Hepatitis Monthly (2015)
11. Does Naringenin Supplementation Improve Lipid Profile, Severity of Hepatic Steatosis and Probability of Liver Fibrosis in Overweight/Obese Patients With Nafld? a Randomised, Double-Blind, Placebo-Controlled, Clinical Trial, International Journal of Clinical Practice (2021)
12. Non-Alcoholic Fatty Liver Disease, Govaresh (2019)
13. The Relationship Between Anthropometric Indices and Non-Alcoholic Fatty Liver Disease in Adults: A Cross-Sectional Study, Frontiers in Nutrition (2024)
14. The Association of Dietary Inflammatory Index (Dii) and Central Obesity With Non-Alcoholic Fatty Liver Disease (Nafld) in People With Diabetes (T2dm), Heliyon (2023)
15. Which Metabolic Index Is Appropriate for Predicting Non-Alcoholic Steatohepatitis?, Middle East Journal of Digestive Diseases (2020)
16. Short-Term Changes on Body Composition After Sleeve Gastrectomy and One Anastomosis Gastric Bypass, Journal of Laparoendoscopic and Advanced Surgical Techniques (2022)
17. Metabolically Healthy and Unhealthy Obesity and the Progression of Liver Fibrosis: A Cross-Sectional Study, Clinics and Research in Hepatology and Gastroenterology (2021)
18. Meta-Analysis: Prevalence Of, and Risk Factors For, Non-Alcoholic Fatty Liver Disease in Patients With Inflammatory Bowel Disease, Alimentary Pharmacology and Therapeutics (2022)
19. Lipid Profile Change After Bariatric Surgeries: Laparoscopic Gastric Plication Versus Mini Gastric Bypass, Acta Chirurgica Belgica (2019)
20. Changes in Fat Mass Index and Fat-Free Mass Index Vary Significantly by Age and Sex of the Patient, and by Type of Bariatric Surgery, Obesity Surgery (2024)