Evaluation of the Association Between Kir Polymorphisms and Systemic Sclerosis: A Meta-Analysis Publisher Pubmed



Karimizadeh E¹ ; Mostafaei S² ; Aslani S¹ ; Gharibdoost F¹ ; Xavier RM³ ; Salim PH³ ; Kavosi H¹ ; Farhadi E^{1, 4} ; Mahmoudi M^{1, 4}
Source: Advances in rheumatology (London# England) Published:2020

Abstract

BACKGROUND: The results of investigations on the association between killer cell immunoglobulin-like receptor (KIR) gene polymorphisms and the risk of systemic sclerosis (SSc) are inconsistent. To comprehensively evaluate the influence of KIR polymorphisms on the risk of SSc, this meta-analysis was performed. METHODS: A systematic literature search was performed in electronic databases including Scopus and PubMed/MEDLINE to find all available studies involving KIR gene family polymorphisms and SSc risk prior to July 2019. Pooled odds ratios (ORs) and their corresponding 95% confidence intervals (CIs) were measured to detect associations between KIR gene family polymorphisms and SSc risk. RESULTS: Five articles, comprising 571 patients and 796 healthy participants, evaluating the KIR gene family polymorphisms were included in the final meta-analysis according to the inclusion and exclusion criteria, and 16 KIR genes were assessed. None of the KIR genes were significantly associated with the risk of SSc. CONCLUSIONS: The current meta-analysis provides evidence that KIR genes might not be potential risk factors for SSc risk.