Association of Ace Gene Polymorphisms With In-Stent Restenosis by Stent Type (Biomime, Supraflex, Xience) Publisher Pubmed



Klashami ZN¹ ; Roudbordeh MG² ; Asadi M^{3, 6} ; Ebrahimi P⁴ ; Amoli MM^{1, 5}
Source: Molecular Biology Reports Published:2023

Abstract

Introduction: Angiotensin Converting Enzyme or ACE is an exo-peptidase that causes the conversion of angiotensin I to angiotensin II, vasoconstriction, and aldosterone production. ACE gene polymorphism (I/D) affects enzyme activity and the risk of coronary artery disease or CAD. Aims: To examine the role of ACE (I/D) Gene Polymorphisms by Stent Types (Biomime, Supraflex, Xience) the Ace gene allele and genotype frequencies were determined in patients who underwent angioplasty. Material & Methods: Patients with in-stent restenosis (ISR+) (N = 53) and patients as non-ISR group (ISR−) (N = 68) have been enrolled in this study based on follow-up angiography > 1 year after PCI. Frequencies of allele and genotypes of the ACE (I/D) variant were determined using polymerase chain reaction (PCR). Results: The genotypes and allele frequencies were not significantly different between the studied populations (p-Values > 0.05). However, there was a significant difference between people with a history of Clopidogrel use in the ISR- and ISR + groups observed (p-Values > 0.005). Conclusion: In the present study, there was no statistically significant relationship between ACE (I/D) gene polymorphism and the incidence of restenosis in patients who underwent repeat angiography. The results showed that the number of patients who received Clopidogrel in the ISR + group was significantly less than the ISR- group. This issue can indicate the inhibitory effect of Clopidogrel in the recurrence of stenosis. © 2023, The Author(s), under exclusive licence to Springer Nature B.V.