Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Targeting Autophagy in Cardiac Ischemia/Reperfusion Injury: A Novel Therapeutic Strategy Publisher Pubmed



Aghaei M1 ; Motallebnezhad M2, 3, 4 ; Ghorghanlu S5 ; Jabbari A5 ; Enayati A5, 6 ; Rajaei M5 ; Pourabouk M5 ; Moradi A7 ; Alizadeh AM8 ; Khori V5
Authors

Source: Journal of Cellular Physiology Published:2019


Abstract

Acute myocardial infarction (AMI) is one of the leading causes of morbidity worldwide. Myocardial reperfusion is known as an effective therapeutic choice against AMI. However, reperfusion of blood flow induces ischemia/reperfusion (I/R) injury through different complex processes including ion accumulation, disruption of mitochondrial membrane potential, the formation of reactive oxygen species, and so forth. One of the processes that gets activated in response to I/R injury is autophagy. Indeed, autophagy acts as a “double-edged sword” in the pathology of myocardial I/R injury and there is a controversy about autophagy being beneficial or detrimental. On the basis of the autophagy effect and regulation on myocardial I/R injury, many studies targeted it as a therapeutic strategy. In this review, we discuss the role of autophagy in I/R injury and its targeting as a therapeutic strategy. © 2019 Wiley Periodicals, Inc.
Other Related Docs
5. The Immunogenetics of Alopecia Areata, Advances in Experimental Medicine and Biology (2022)
6. Mitochondria Signaling Pathways in Allergic Asthma, Journal of Investigative Medicine (2022)
14. Novel Therapeutic Strategies for Stroke: The Role of Autophagy, Critical Reviews in Clinical Laboratory Sciences (2019)
16. Implications on the Therapeutic Potential of Statins Via Modulation of Autophagy, Oxidative Medicine and Cellular Longevity (2021)
19. Autophagy in Cancers Including Brain Tumors: Role of Micrornas, Cell Communication and Signaling (2020)