Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Association Between Human Epstein-Barr Virus and Brain Cancer: A Systematic Review and Meta-Analysis Publisher



Ghorbani S1, 2 ; Tambrchi V3 ; Farzi R4 ; Khatami A1 ; Samiei RN1 ; Saadati H5 ; Noori M6, 7 ; Letafati A8 ; Bahavar A3 ; Hezarpishe N9 ; Musavioun M10 ; Mirzaei B11 ; Meftagh MS12 ; Doust NK13 Show All Authors
Authors
  1. Ghorbani S1, 2
  2. Tambrchi V3
  3. Farzi R4
  4. Khatami A1
  5. Samiei RN1
  6. Saadati H5
  7. Noori M6, 7
  8. Letafati A8
  9. Bahavar A3
  10. Hezarpishe N9
  11. Musavioun M10
  12. Mirzaei B11
  13. Meftagh MS12
  14. Doust NK13
  15. Hejami F14
  16. Kiani SJ1

Source: Future Virology Published:2023


Abstract

Aim: The aim of this study was to investigate the pooled prevalence and potential correlation between Epstein-Barr virus (EBV) infection and brain cancers. Materials & methods: We searched for relevant studies in main databases and analyzed the heterogeneity, odds ratio and corresponding 95% CI among all studies using STATA software V.14. Results: Fourteen articles were included in the meta-analysis. The pooled prevalence of EBV among brain cancer patients was 9% (95% CI: 3-16%; I2 = 91.06%). An association was found between EBV and brain cancer (OR: 6.90 [95% CI: 1.81-26.28]; I2 = 0%]). Conclusion: The results of this study indicate a significant association between EBV infection and brain cancer, suggesting EBV infection is a potential risk factor for brain cancer development. © 2023 Future Medicine Ltd.
Related Docs
View other Related Docs
1. Exploring Ebna1-Mediated Regulation of Key Cellular Genes in Glioblastoma Multiforme: Implications for Ebv-Associated Pathogenesis, Iranian Journal of Medical Microbiology (2024)
2. Epstein-Barr Virus and Risk of Breast Cancer: A Systematic Review and Meta-Analysis, Future Oncology (2019)
3. Association Between Human Herpesvirus-6 and Primary Brain Tumors: A Systematic Review and Meta-Analysis, Future Virology (2022)
Experts (# of related papers)
View all Related Experts
Nima Rezaei (1)
Ashraf Mohammadkhani (1)
Other Related Docs
4. Molecular Investigation of Human Cytomegalovirus and Epstein-Barr Virus in Glioblastoma Brain Tumor: A Case-Control Study in Iran, Iranian Biomedical Journal (2021)
5. Association Between Human Polyomavirus Infection and Brain Cancer: A Systematic Review and Meta-Analysis, Microbial Pathogenesis (2022)
6. Evaluation of Cellular Mir-122 Expression in Association With the Presence of Varicella-Zoster Virus Among Central Nervous System Tumors, International Journal of Cancer Management (2022)
7. Epstein-Barr Virus Nuclear Antigen 1 (Ebna1) Increases the Expression Levels of Mdm2 and Mdm4 Genes in Hela Cells: A Review on Mdm2 and Mdm4 Roles in Cancer, BMC Research Notes (2025)
8. Human Cytomegalovirus and Epstein-Barr Virus Infections in Breast Cancer: A Molecular Study on Iranian Women, Breast Disease (2021)
9. A Comprehensive Study of Prostate Cancer and Epstein-Barr Virus Infection: A Systematic Review and Meta-Analysis, Iranian Journal of Blood and Cancer (2025)
10. The Prevalence of Epstein-Barr Virus in Normal, Premalignant, and Malignant Uterine Cervical Samples in Iran, Intervirology (2024)
11. Association Between Epstein-Bar Virus and Colorectal Cancer: A Systematic Review and Meta-Analysis, Microbial Pathogenesis (2023)
12. Serostatus of Epstein–Barr Virus in Iranian Ms Patients, Acta Neurologica Belgica (2016)
13. Association Between Epstein-Barr Virus Infection and Gastric Cancer: A Systematic Review and Meta-Analysis, BMC Cancer (2020)
14. Combined Immunodeficiency and Epstein-Barr Virus- Induced B Cell Malignancy in Humans With Inherited Cd70 Deficiency, Journal of Experimental Medicine (2017)
15. Epstein–Barr Virus and Thyroid Cancer: The Role of Viral Expressed Proteins, Journal of Cellular Physiology (2019)
16. Alzheimer’S Disease and Infectious Agents: A Comprehensive Review of Pathogenic Mechanisms and Microrna Roles, Frontiers in Neuroscience (2024)
17. Review on the Most Important Viruses in Oral Squamous Cell Carcinomas, Pakistan Journal of Medical and Health Sciences (2020)
18. Association Between Epstein Barr Virus and Tongue Squamous Cell Carcinoma in Iranian Patients, Pathology Research and Practice (2018)
19. Seroprevalence of Epstein–Barr Virus Among Children and Adults in Tehran, Iran, New Microbes and New Infections (2020)
20. Insights Into the Interplay Between Epstein-Barr Virus (Ebv) and Multiple Sclerosis (Ms): A State-Of-The-Art Review and Implications for Vaccine Development, Health Science Reports (2024)