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Expression Analysis of Apoptosis-Related Genes in Bladder Cancer Patients Publisher



Yazarlou F1 ; Afsharpad M2 ; Oskooei VK3 ; Nekoohesh L4 ; Moharrami T5 ; Samadaian N1 ; Ghafourifard S3 ; Modarressi MH1, 6
Authors

Source: Meta Gene Published:2018


Abstract

Background: Bladder cancer (BC) is a frequent cancer with high morbidity and mortality. Method: We assessed expression of NMP22, BAG3, BCL2 and BAX in BC samples, adjacent non-neoplastic tissues (ANNTs), urinary cell pellets (UCP) of the same patients and non-malignant conditions (NM). Results: NMP22 was up-regulated in tumoral tissues compared with ANNTs and in UCP of BC patients compared with UCP of NM. BCL2 and BAX were down-regulated in BC tissues compared with ANNTs. BAG3 and BAX were down-regulated in UCP of BC compared with NM. The combination of all four genes had 100% sensitivity and specificity for detection of BC in urine. Conclusion: Expression analysis of these genes in tumor or urine is a tool for detection of BC. © 2018
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