Hif-1Α and Vegf Polymorphisms and Systemic Lupus Erythematosus Susceptibility Publisher



Saravani M^{1, 2} ; Sandoughi M³ ; Heidary Z⁴ ; Ebrahimi G⁵ ; Mirzamohammadi S⁶ ; Haddadi M⁷ ; Nematollahi MH^{8, 9}
Source: Meta Gene Published:2021

Abstract

Background: Hypoxia-inducible factor-1α (HIF-1α) and its downstream gene, vascular endothelial factor (VEGF), play an important role in modulating the immune system function and consequently alternation the susceptibility to systemic lupus erythematosus (SLE) disease. Objective: The present study aimed to investigate the effect of the HIF-1α and VEGF gene polymorphisms and the susceptibility to SLE. Methods: The 140 patients and 150 healthy age and gender-matched people as a control group participated in the study. The PCR-RFLP method was used for genotyping. Results: No remarkable differences in allele frequencies of HIF-1α (rs11549465) and VEGF (rs699947) were seen between the SLE and control groups. The frequencies of CT genotype of the HIF-1α (rs11549465) and CA genotype of VEGF (rs699947) in the control were significantly higher than SLE group (OR = 0.53; 95% CI = 0.32–0.53; p = 0.014; OR = 0.57;95% CI = 0.33–0.99; p = 0.046, resp.). In the case of HIF-1α (C111A) polymorphism, the CA and AA variants were not found. Conclusion: HIF-1α (rs11549465) CT and VEGF (rs699947) CA genotypes were identified as protective factors for SLE. However, additional studies are required to confirm the association between HIF-1α and VEGF polymorphisms and SLE. © 2021