Role of the Wnt and Gtpase Pathways in Breast Cancer Tumorigenesis and Treatment

Role of the Wnt and Gtpase Pathways in Breast Cancer Tumorigenesis and Treatment Publisher Pubmed

Ebrahimi N¹ ; Kharazmi K² ; Ghanaatian M³ ; Miraghel SA⁴ ; Amiri Y⁵ ; Seyedebrahimi SS⁶ ; Mobarak H⁷ ; Yazdani E^{8, 9} ; Parkhideh S¹⁰ ; Hamblin MR¹¹ ; Aref AR¹²

Source: Cytokine and Growth Factor Reviews Published:2022

Abstract

Breast cancer (BC) is the most frequently diagnosed cancer among women in all the populations of the world. Although the BC mortality rate has declined, resistance to treatment is still a significant challenge for patient survival. Various cellular signaling pathways, such as Wnt and Rho/GTPase have been linked to the development, migration, and metastasis of BC, and also in treatment resistance mechanisms. Some studies have shown an association between two important cellular pathways, Wnt and Rho/GTPase, in cytoskeleton activation and cancer invasion. However, their involvement in BC has received little attention. This review summarizes the Wnt and Rho/GTPases signaling pathway functions, and also the crosstalk between these pathways in the progression, metastasis, and drug resistance mechanisms in BC. Considering the signaling pathways involved in BC tumorigenesis, future studies will need to investigate possible molecular interventions and new opportunities for the development of personalized strategies for BC treatment in order to improve overall outcomes. © 2022 Elsevier Ltd

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Style	Citing Format
MLA	Ebrahimi N, et al.. "Role of the Wnt and Gtpase Pathways in Breast Cancer Tumorigenesis and Treatment." Cytokine and Growth Factor Reviews, vol. 67, no. , 2022, pp. 11-24.
APA	Ebrahimi N, Kharazmi K, Ghanaatian M, Miraghel SA, Amiri Y, Seyedebrahimi SS, Mobarak H, Yazdani E, Parkhideh S, Hamblin MR, Aref AR (2022). Role of the Wnt and Gtpase Pathways in Breast Cancer Tumorigenesis and Treatment. Cytokine and Growth Factor Reviews, 67(), 11-24.
Chicago	Ebrahimi N, Kharazmi K, Ghanaatian M, Miraghel SA, Amiri Y, Seyedebrahimi SS, Mobarak H, et al.. "Role of the Wnt and Gtpase Pathways in Breast Cancer Tumorigenesis and Treatment." Cytokine and Growth Factor Reviews 67, no. (2022): 11-24.
Harvard	Ebrahimi N et al. (2022) 'Role of the Wnt and Gtpase Pathways in Breast Cancer Tumorigenesis and Treatment', Cytokine and Growth Factor Reviews, 67(), pp. 11-24.
Vancouver	Ebrahimi N, Kharazmi K, Ghanaatian M, Miraghel SA, Amiri Y, Seyedebrahimi SS, et al.. Role of the Wnt and Gtpase Pathways in Breast Cancer Tumorigenesis and Treatment. Cytokine and Growth Factor Reviews. 2022;67():11-24.
BibTex	@article{ author = {Ebrahimi N and Kharazmi K and Ghanaatian M and Miraghel SA and Amiri Y and Seyedebrahimi SS and Mobarak H and Yazdani E and Parkhideh S and Hamblin MR and Aref AR}, title = {Role of the Wnt and Gtpase Pathways in Breast Cancer Tumorigenesis and Treatment}, journal = {Cytokine and Growth Factor Reviews}, volume = {67}, number = {}, pages = {11-24}, year = {2022} }
RIS	TY - JOUR AU - Ebrahimi N AU - Kharazmi K AU - Ghanaatian M AU - Miraghel SA AU - Amiri Y AU - Seyedebrahimi SS AU - Mobarak H AU - Yazdani E AU - Parkhideh S AU - Hamblin MR AU - Aref AR TI - Role of the Wnt and Gtpase Pathways in Breast Cancer Tumorigenesis and Treatment JO - Cytokine and Growth Factor Reviews VL - 67 IS - SP - 11 EP - 24 PY - 2022 ER -

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