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Appel Reagent As Novel Promoter for the Synthesis of Polysubstituted Imidazoles Publisher



Khoshneviszadeh M1 ; Mahdavi M2
Authors

Source: Arkivoc Published:2017


Abstract

We present an efficient method for the synthesis of polysubstituted imidazoles in the presence of Appel reagent (Ph3P/CCl4). Tri-substituted imidazoles is synthesized via condensation of aldehydes, benzil and ammonium acetate, and tetra-substituted imidazole is prepared via condensation of aldehydes, benzil, ammonium acetate and primary amines. These protocols allow the simple preparation of the desired products using readily available reagent instead of complex, expensive and toxic reagents under mild reaction conditions in excellent yields. © 2016 Arkat. All rights reserved.
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