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A Systematic Review and Meta-Analysis of Randomized Controlled Trials to Evaluating the Trend of Cytokines to Vitamin a Supplementation in Autoimmune Diseases Publisher Pubmed



Harirchian MH1 ; Mohammadpour Z1, 2 ; Fatehi F1 ; Firoozeh N1 ; Bitarafan S1
Authors

Source: Clinical Nutrition Published:2019


Abstract

Background & aims: Vitamin A is considered as a supplement that effect on autoimmune diseases. We aimed to systematically review the effect of vitamin A on cytokines in patients with autoimmune disease. Methods: Two researchers searched Scopus and PubMed until May 2018. Researchers extracted data from 6 eligible published papers. Extracted data included the gene expression of the inflammatory and anti-inflammatory cytokines. Results: Fixed effect analysis of the WMD (95% CI) of the changes in gene expression showed that gene expression of the inflammatory (IL-17, IFN-γ and T-bet) and anti-inflammatory (TGF-β and FOXP3) cytokines significantly decreased and increased due to vitamin A supplementation in patients with autoimmune (Multiple sclerosis and atherosclerosis) diseases. Conclusions: Vitamin A supplementation effects on gene expression and may improve serum level of cytokines and clinical signs of autoimmune disease but there is no adequate evidence. © 2018 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism
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