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The Interplay Between Gut Microbiota and Autism Spectrum Disorders: A Focus on Immunological Pathways Publisher Pubmed



Moradi K1 ; Ashrafganjouei A1 ; Tavolinejad H1 ; Bagheri S1 ; Akhondzadeh S1
Authors

Source: Progress in Neuro-Psychopharmacology and Biological Psychiatry Published:2021


Abstract

Autism spectrum disorders (ASD) are a group of neurodevelopmental disorders characterized by impairments in social and cognitive activities, stereotypical and repetitive behaviors and restricted areas of interest. A remarkable proportion of ASD patients represent immune dysregulation as well as gastrointestinal complications. Hence, a novel concept has recently emerged, addressing the possible intercommunication between the brain, the immune system, the gut and its commensals. Here, we provide an overview of how gut microbes and their metabolites are associated with neurobehavioral features of ASD through various immunologic mechanisms. Moreover, we discuss the potential therapeutic options that could modify these features. © 2020 Elsevier Inc.
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