Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
The Footprint of Exosomes in the Radiation-Induced Bystander Effects Publisher



Jokar S1, 2, 3, 4 ; Marques IA2, 3, 4, 5, 6 ; Khazaei S7 ; Martinsmarques T3, 4, 8 ; Girao H3, 4, 8 ; Laranjo M2, 3, 4, 5, 8 ; Botelho MF2, 3, 4, 5, 8
Authors

Source: Bioengineering Published:2022


Abstract

Radiation therapy is widely used as the primary treatment option for several cancer types. However, radiation therapy is a nonspecific method and associated with significant challenges such as radioresistance and non-targeted effects. The radiation-induced non-targeted effects on nonirradiated cells nearby are known as bystander effects, while effects far from the ionising radiation-exposed cells are known as abscopal effects. These effects are presented as a consequence of intercellular communi-cations. Therefore, a better understanding of the involved intercellular signals may bring promising new strategies for radiation risk assessment and potential targets for developing novel radiotherapy strategies. Recent studies indicate that radiation-derived extracellular vesicles, particularly exosomes, play a vital role in intercellular communications and may result in radioresistance and non-targeted effects. This review describes exosome biology, intercellular interactions, and response to different environmental stressors and diseases, and focuses on their role as functional mediators in inducing radiation-induced bystander effect (RIBE). © 2022 by the authors. Licensee MDPI, Basel, Switzerland.
Other Related Docs
9. Glioma and Exosome, Letters in Applied NanoBioScience (2022)
10. Exosomes and Micrornas in Biomedical Science, Synthesis Lectures on Biomedical Engineering (2022)
14. Exosomes, Autophagy and Er Stress Pathways in Human Diseases: Cross-Regulation and Therapeutic Approaches, Biochimica et Biophysica Acta - Molecular Basis of Disease (2022)