Double Targeting, Controlled Release and Reversible Delivery of Daunorubicin to Cancer Cells by Polyvalent Aptamers-Modified Gold Nanoparticles

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Double Targeting, Controlled Release and Reversible Delivery of Daunorubicin to Cancer Cells by Polyvalent Aptamers-Modified Gold Nanoparticles Publisher Pubmed

Taghdisi SM¹ ; Danesh NM^{2, 3} ; Lavaee P^{4, 5} ; Emrani AS⁶ ; Hassanabad KY⁷ ; Ramezani M² ; Abnous K⁸

Source: Materials Science and Engineering C Published:2016

Abstract

Clinical use of daunorubicin (Dau) in treatment of leukemia has been restricted because of its cardiotoxicity. Targeted delivery of anticancer drugs could decrease their off-target effects and enhance their efficacy. In this study a modified polyvalent aptamers (PA)-Daunorubicin (Dau)-Gold nanoparticles (AuNPs) complex was designed and its efficacy was assessed in Molt-4 cells (human acute lymphoblastic leukemia T-cell, target). Dau was efficiently loaded (10.5 μM) onto 1 mL of PA-modified AuNPs. Dau was released from the PA-Dau-AuNPs complex in a pH-sensitive manner (faster release at pH 5.5). The results of flow cytometry analysis indicated that the PA-Dau-AuNPs complex was efficiently internalized into target cells, but not into nontarget cells. The results of MTT assay were consistent with the internalization data. PA-Dau-AuNPs complex had less cytotoxicity in U266 cells compared to Dau alone and even Apt-Dau-AuNPs complex. The PA-Dau-AuNPs complex had more cytotoxicity in Molt-4 cells compared to Dau alone and even Apt-Dau-AuNPs complex. Cytotoxicity of PA-Dau-AuNPs complex was effectively antagonized using antisense of polyvalent aptamers. In conclusion, the designed drug delivery system inherited the properties of efficient drug loading, tumor targeting, pH-dependent drug release and controllable delivery of Dau to tumor cells. © 2016 Elsevier B.V. All rights reserved.

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Style	Citing Format
MLA	Taghdisi SM, et al.. "Double Targeting, Controlled Release and Reversible Delivery of Daunorubicin to Cancer Cells by Polyvalent Aptamers-Modified Gold Nanoparticles." Materials Science and Engineering C, vol. 61, no. , 2016, pp. 753-761.
APA	Taghdisi SM, Danesh NM, Lavaee P, Emrani AS, Hassanabad KY, Ramezani M, Abnous K (2016). Double Targeting, Controlled Release and Reversible Delivery of Daunorubicin to Cancer Cells by Polyvalent Aptamers-Modified Gold Nanoparticles. Materials Science and Engineering C, 61(), 753-761.
Chicago	Taghdisi SM, Danesh NM, Lavaee P, Emrani AS, Hassanabad KY, Ramezani M, Abnous K. "Double Targeting, Controlled Release and Reversible Delivery of Daunorubicin to Cancer Cells by Polyvalent Aptamers-Modified Gold Nanoparticles." Materials Science and Engineering C 61, no. (2016): 753-761.
Harvard	Taghdisi SM et al. (2016) 'Double Targeting, Controlled Release and Reversible Delivery of Daunorubicin to Cancer Cells by Polyvalent Aptamers-Modified Gold Nanoparticles', Materials Science and Engineering C, 61(), pp. 753-761.
Vancouver	Taghdisi SM, Danesh NM, Lavaee P, Emrani AS, Hassanabad KY, Ramezani M, et al.. Double Targeting, Controlled Release and Reversible Delivery of Daunorubicin to Cancer Cells by Polyvalent Aptamers-Modified Gold Nanoparticles. Materials Science and Engineering C. 2016;61():753-761.
BibTex	@article{ author = {Taghdisi SM and Danesh NM and Lavaee P and Emrani AS and Hassanabad KY and Ramezani M and Abnous K}, title = {Double Targeting, Controlled Release and Reversible Delivery of Daunorubicin to Cancer Cells by Polyvalent Aptamers-Modified Gold Nanoparticles}, journal = {Materials Science and Engineering C}, volume = {61}, number = {}, pages = {753-761}, year = {2016} }
RIS	TY - JOUR AU - Taghdisi SM AU - Danesh NM AU - Lavaee P AU - Emrani AS AU - Hassanabad KY AU - Ramezani M AU - Abnous K TI - Double Targeting, Controlled Release and Reversible Delivery of Daunorubicin to Cancer Cells by Polyvalent Aptamers-Modified Gold Nanoparticles JO - Materials Science and Engineering C VL - 61 IS - SP - 753 EP - 761 PY - 2016 ER -

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