Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
A Methodological Checklist for Fmri Drug Cue Reactivity Studies: Development and Expert Consensus Publisher Pubmed



Ekhtiari H1, 2 ; Zarebidoky M3, 4 ; Sangchooli A3 ; Janes AC5 ; Kaufman MJ5 ; Oliver JA6, 7, 8 ; Prisciandaro JJ9 ; Wustenberg T10 ; Anton RF9 ; Bach P11 ; Baldacchino A12 ; Beck A10, 13 ; Bjork JM14 ; Brewer J15 Show All Authors
Authors
  1. Ekhtiari H1, 2
  2. Zarebidoky M3, 4
  3. Sangchooli A3
  4. Janes AC5
  5. Kaufman MJ5
  6. Oliver JA6, 7, 8
  7. Prisciandaro JJ9
  8. Wustenberg T10
  9. Anton RF9
  10. Bach P11
  11. Baldacchino A12
  12. Beck A10, 13
  13. Bjork JM14
  14. Brewer J15
  15. Childress AR16
  16. Claus ED17
  17. Courtney KE18
  18. Ebrahimi M3
  19. Filbey FM19
  20. Ghahremani DG20
  21. Azbari PG3, 21
  22. Goldstein RZ22
  23. Goudriaan AE23
  24. Grodin EN20
  25. Hamilton JP24, 25
  26. Hanlon CA26
  27. Hassaniabharian P27
  28. Heinz A10
  29. Joseph JE28
  30. Kiefer F11
  31. Zonoozi AK3, 29
  32. Kober H30
  33. Kuplicki R1
  34. Li Q31
  35. London ED20
  36. Mcclernon J6
  37. Noori HR32, 33
  38. Owens MM34
  39. Paulus MP1
  40. Perini I24, 25
  41. Potenza M30, 35, 36, 37
  42. Potvin S38
  43. Ray L20
  44. Schacht JP39
  45. Seo D30
  46. Sinha R30
  47. Smolka MN40
  48. Spanagel R41
  49. Steele VR30
  50. Stein EA42
  51. Steinsloeber S43
  52. Tapert SF18
  53. Verdejogarcia A44
  54. Vollstadtklein S11
  55. Wetherill RR16
  56. Wilson SJ45
  57. Witkiewitz K46
  58. Yuan K47
  59. Zhang X48, 49
  60. Zilverstand A2

Source: Nature Protocols Published:2022


Abstract

Cue reactivity is one of the most frequently used paradigms in functional magnetic resonance imaging (fMRI) studies of substance use disorders (SUDs). Although there have been promising results elucidating the neurocognitive mechanisms of SUDs and SUD treatments, the interpretability and reproducibility of these studies is limited by incomplete reporting of participants’ characteristics, task design, craving assessment, scanning preparation and analysis decisions in fMRI drug cue reactivity (FDCR) experiments. This hampers clinical translation, not least because systematic review and meta-analysis of published work are difficult. This consensus paper and Delphi study aims to outline the important methodological aspects of FDCR research, present structured recommendations for more comprehensive methods reporting and review the FDCR literature to assess the reporting of items that are deemed important. Forty-five FDCR scientists from around the world participated in this study. First, an initial checklist of items deemed important in FDCR studies was developed by several members of the Enhanced NeuroImaging Genetics through Meta-Analyses (ENIGMA) Addiction working group on the basis of a systematic review. Using a modified Delphi consensus method, all experts were asked to comment on, revise or add items to the initial checklist, and then to rate the importance of each item in subsequent rounds. The reporting status of the items in the final checklist was investigated in 108 recently published FDCR studies identified through a systematic review. By the final round, 38 items reached the consensus threshold and were classified under seven major categories: ‘Participants’ Characteristics’, ‘General fMRI Information’, ‘General Task Information’, ‘Cue Information’, ‘Craving Assessment Inside Scanner’, ‘Craving Assessment Outside Scanner’ and ‘Pre- and Post-Scanning Considerations’. The review of the 108 FDCR papers revealed significant gaps in the reporting of the items considered important by the experts. For instance, whereas items in the ‘General fMRI Information’ category were reported in 90.5% of the reviewed papers, items in the ‘Pre- and Post-Scanning Considerations’ category were reported by only 44.7% of reviewed FDCR studies. Considering the notable and sometimes unexpected gaps in the reporting of items deemed to be important by experts in any FDCR study, the protocols could benefit from the adoption of reporting standards. This checklist, a living document to be updated as the field and its methods advance, can help improve experimental design, reporting and the widespread understanding of the FDCR protocols. This checklist can also provide a sample for developing consensus statements for protocols in other areas of task-based fMRI. © 2021, The Author(s), under exclusive licence to Springer Nature Limited.
Other Related Docs