Infants Hospitalized for Acute Covid-19: Disease Severity in a Multicenter Cohort Study

Infants Hospitalized for Acute Covid-19: Disease Severity in a Multicenter Cohort Study Publisher Pubmed

Merckx J¹ ; Morris SK² ; Bitnun A² ; Gill P² ; El Tal T² ; Laxer RM² ; Yeh A² ; Yea C² ; Ulloagutierrez R³ ; Breneschacon H³ ; Yockcorrales A³ ; Ivankovichescoto G³ ; Sorianofallas A³ ; Hernandezde Mezerville M³ Show All Authors

Merckx J¹
Morris SK²
Bitnun A²
Gill P²
El Tal T²
Laxer RM²
Yeh A²
Yea C²
Ulloagutierrez R³
Breneschacon H³
Yockcorrales A³
Ivankovichescoto G³
Sorianofallas A³
Hernandezde Mezerville M³
Papenburg J^{1, 4}
Lefebvre MA⁴
Nateghian A⁵
Haghighi Aski B⁵
Manafi A⁵
Dwilow R⁶
Bullard J⁶
Cooke S⁷
Dewan T⁷
Restivo L⁷
Lopez A⁸
Sadarangani M^{8, 9, 10}
Roberts A^{8, 9}
Barton M¹¹
Petel D¹¹
Le Saux N¹²
Bowes J¹²
Purewal R¹³
Lautermilch J¹³
Tehseen S¹³
Bayliss A¹⁴
Wong JK¹⁵
Vieltheriault I¹⁶
Piche D¹⁷
Top KA¹⁷
Leifso K¹⁸
Foo C¹⁹
Panetta L²⁰
Robinson J²¹

Source: European Journal of Pediatrics Published:2022

Abstract

Age is the most important determinant of COVID-19 severity. Infectious disease severity by age is typically J-shaped, with infants and the elderly carrying a high burden of disease. We report on the comparative disease severity between infants and older children in a multicenter retrospective cohort study of children 0 to 17 years old admitted for acute COVID-19 from February 2020 through May 2021 in 17 pediatric hospitals. We compare clinical and laboratory characteristics and estimate the association between age group and disease severity using ordinal logistic regression. We found that infants comprised one-third of cases, but were admitted for a shorter period (median 3 days IQR 2–5 versus 4 days IQR 2–7), had a lower likelihood to have an increased C-reactive protein, and had half the odds of older children of having severe or critical disease (OR 0.50 (95% confidence interval 0.32–0.78)). Conclusion: When compared to older children, there appeared to be a lower threshold to admit infants but their length of stay was shorter and they had lower odds than older children of progressing to severe or critical disease.What is Known:• A small proportion of children infected with SARS-CoV-2 require hospitalization for acute COVID-19 with a subgroup needing specialized intensive care to treat more severe disease.• For most infectious diseases including viral respiratory tract infections, disease severity by age is J-shaped, with infants having more severe disease compared to older children.What is New:• One-third of admitted children for acute COVID-19 during the first 14 months of the pandemic were infants.• Infants had half the odds of older children of having severe or critical disease. © 2022, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

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Style	Citing Format
MLA	Merckx J, et al.. "Infants Hospitalized for Acute Covid-19: Disease Severity in a Multicenter Cohort Study." European Journal of Pediatrics, vol. , no. , 2022, pp. -.
APA	Merckx J, Morris SK, Bitnun A, Gill P, El Tal T, Laxer RM, Yeh A, Yea C, Ulloagutierrez R, Breneschacon H, Yockcorrales A, Ivankovichescoto G, Sorianofallas A, Hernandezde Mezerville M, Papenburg J, Lefebvre MA, Nateghian A, Haghighi Aski B, Manafi A, ... Robinson J (2022). Infants Hospitalized for Acute Covid-19: Disease Severity in a Multicenter Cohort Study. European Journal of Pediatrics, (), -.
Chicago	Merckx J, Morris SK, Bitnun A, Gill P, El Tal T, Laxer RM, Yeh A, et al.. "Infants Hospitalized for Acute Covid-19: Disease Severity in a Multicenter Cohort Study." European Journal of Pediatrics , no. (2022): -.
Harvard	Merckx J et al. (2022) 'Infants Hospitalized for Acute Covid-19: Disease Severity in a Multicenter Cohort Study', European Journal of Pediatrics, (), pp. -.
Vancouver	Merckx J, Morris SK, Bitnun A, Gill P, El Tal T, Laxer RM, et al.. Infants Hospitalized for Acute Covid-19: Disease Severity in a Multicenter Cohort Study. European Journal of Pediatrics. 2022;():-.
BibTex	@article{ author = {Merckx J and Morris SK and Bitnun A and Gill P and El Tal T and Laxer RM and Yeh A and Yea C and Ulloagutierrez R and Breneschacon H and Yockcorrales A and Ivankovichescoto G and Sorianofallas A and Hernandezde Mezerville M and Papenburg J and Lefebvre MA and Nateghian A and Haghighi Aski B and Manafi A and Dwilow R and Bullard J and Cooke S and Dewan T and Restivo L and Lopez A and Sadarangani M and Roberts A and Barton M and Petel D and Le Saux N and Bowes J and Purewal R and Lautermilch J and Tehseen S and Bayliss A and Wong JK and Vieltheriault I and Piche D and Top KA and Leifso K and Foo C and Panetta L and Robinson J}, title = {Infants Hospitalized for Acute Covid-19: Disease Severity in a Multicenter Cohort Study}, journal = {European Journal of Pediatrics}, volume = {}, number = {}, pages = {-}, year = {2022} }
RIS	TY - JOUR AU - Merckx J AU - Morris SK AU - Bitnun A AU - Gill P AU - El Tal T AU - Laxer RM AU - Yeh A AU - Yea C AU - Ulloagutierrez R AU - Breneschacon H AU - Yockcorrales A AU - Ivankovichescoto G AU - Sorianofallas A AU - Hernandezde Mezerville M AU - Papenburg J AU - Lefebvre MA AU - Nateghian A AU - Haghighi Aski B AU - Manafi A AU - Dwilow R AU - Bullard J AU - Cooke S AU - Dewan T AU - Restivo L AU - Lopez A AU - Sadarangani M AU - Roberts A AU - Barton M AU - Petel D AU - Le Saux N AU - Bowes J AU - Purewal R AU - Lautermilch J AU - Tehseen S AU - Bayliss A AU - Wong JK AU - Vieltheriault I AU - Piche D AU - Top KA AU - Leifso K AU - Foo C AU - Panetta L AU - Robinson J TI - Infants Hospitalized for Acute Covid-19: Disease Severity in a Multicenter Cohort Study JO - European Journal of Pediatrics VL - IS - SP - EP - PY - 2022 ER -

Style

Citing Format

MLA

Merckx J, et al.. "Infants Hospitalized for Acute Covid-19: Disease Severity in a Multicenter Cohort Study." European Journal of Pediatrics, vol. , no. , 2022, pp. -.

APA

Merckx J, Morris SK, Bitnun A, Gill P, El Tal T, Laxer RM, Yeh A, Yea C, Ulloagutierrez R, Breneschacon H, Yockcorrales A, Ivankovichescoto G, Sorianofallas A, Hernandezde Mezerville M, Papenburg J, Lefebvre MA, Nateghian A, Haghighi Aski B, Manafi A, ... Robinson J (2022). Infants Hospitalized for Acute Covid-19: Disease Severity in a Multicenter Cohort Study. European Journal of Pediatrics, (), -.

Chicago

Merckx J, Morris SK, Bitnun A, Gill P, El Tal T, Laxer RM, Yeh A, et al.. "Infants Hospitalized for Acute Covid-19: Disease Severity in a Multicenter Cohort Study." European Journal of Pediatrics , no. (2022): -.

Harvard

Merckx J et al. (2022) 'Infants Hospitalized for Acute Covid-19: Disease Severity in a Multicenter Cohort Study', European Journal of Pediatrics, (), pp. -.

Vancouver

Merckx J, Morris SK, Bitnun A, Gill P, El Tal T, Laxer RM, et al.. Infants Hospitalized for Acute Covid-19: Disease Severity in a Multicenter Cohort Study. European Journal of Pediatrics. 2022;():-.

BibTex

@article{ author = {Merckx J and Morris SK and Bitnun A and Gill P and El Tal T and Laxer RM and Yeh A and Yea C and Ulloagutierrez R and Breneschacon H and Yockcorrales A and Ivankovichescoto G and Sorianofallas A and Hernandezde Mezerville M and Papenburg J and Lefebvre MA and Nateghian A and Haghighi Aski B and Manafi A and Dwilow R and Bullard J and Cooke S and Dewan T and Restivo L and Lopez A and Sadarangani M and Roberts A and Barton M and Petel D and Le Saux N and Bowes J and Purewal R and Lautermilch J and Tehseen S and Bayliss A and Wong JK and Vieltheriault I and Piche D and Top KA and Leifso K and Foo C and Panetta L and Robinson J}, title = {Infants Hospitalized for Acute Covid-19: Disease Severity in a Multicenter Cohort Study}, journal = {European Journal of Pediatrics}, volume = {}, number = {}, pages = {-}, year = {2022} }

RIS

TY - JOUR
AU - Merckx J
AU - Morris SK
AU - Bitnun A
AU - Gill P
AU - El Tal T
AU - Laxer RM
AU - Yeh A
AU - Yea C
AU - Ulloagutierrez R
AU - Breneschacon H
AU - Yockcorrales A
AU - Ivankovichescoto G
AU - Sorianofallas A
AU - Hernandezde Mezerville M
AU - Papenburg J
AU - Lefebvre MA
AU - Nateghian A
AU - Haghighi Aski B
AU - Manafi A
AU - Dwilow R
AU - Bullard J
AU - Cooke S
AU - Dewan T
AU - Restivo L
AU - Lopez A
AU - Sadarangani M
AU - Roberts A
AU - Barton M
AU - Petel D
AU - Le Saux N
AU - Bowes J
AU - Purewal R
AU - Lautermilch J
AU - Tehseen S
AU - Bayliss A
AU - Wong JK
AU - Vieltheriault I
AU - Piche D
AU - Top KA
AU - Leifso K
AU - Foo C
AU - Panetta L
AU - Robinson J
TI - Infants Hospitalized for Acute Covid-19: Disease Severity in a Multicenter Cohort Study
JO - European Journal of Pediatrics
VL -
IS -
SP -
EP -
PY - 2022
ER -

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Abstract