Short-Term Effects of Particle Size Fractions on Circulating Biomarkers of Inflammation in a Panel of Elderly Subjects and Healthy Young Adults Publisher Pubmed



Hassanvand MS^{1, 2} ; Naddafi K^{1, 2} ; Kashani H³ ; Faridi S² ; Kunzli N^{4, 5} ; Nabizadeh R^{1, 2} ; Momeniha F⁶ ; Gholampour A⁷ ; Arhami M⁸ ; Zare A⁹ ; Pourpak Z⁹ ; Hoseini M¹⁰ ; Yunesian M^{1, 2}
Source: Environmental Pollution Published:2017

Abstract

Systemic inflammation biomarkers have been associated with risk of cardiovascular morbidity and mortality. We aimed to clarify associations of acute exposure to particulate matter (PM10(PM < 10 μm), PM2.5-10(PM 2.5–10 μm), PM2.5(PM < 2.5 μm), PM1-2.5(PM 1–2.5 μm), and PM1 (PM < 1 μm)) with systemic inflammation using panels of elderly subjects and healthy young adults. We followed a panel of 44 nonsmoking elderly subjects living in a retirement home and a panel of 40 healthy young adults living in a school dormitory in Tehran city, Iran from May 2012 to May 2013. Blood biomarkers were measured one every 7–8 weeks and included white blood cells (WBC), high sensitive C-reactive protein (hsCRP), tumor necrosis factor-soluble receptor-II (sTNF-RII), interleukin-6 (IL-6), and von Willebrand factor (vWF). We measured hourly indoor and outdoor exposure to PM10, PM2.5-10, PM2.5, PM1-2.5, and PM1mass concentration to derive weighted averages of personal exposure based on simultaneously collected time-activity data. The random intercept linear mixed effects model was used for data analysis. We observed significant positive associations for WBC and IL-6 with exposure to PM10, PM2.5-10, PM2.5, PM1-2.5, and PM1; sTNF-RII with PM2.5, PM1-2.5, and PM1; hsCRP with PM2.5and PM1; and vWF with PM10and PM2.5-10, PM2.5, and PM1-2.5mass concentration in elderly subjects from the current-day and multiday averages. For healthy young adults, we found significant positive associations for WBC and IL-6 with exposure to PM10, PM2.5-10, PM2.5, and PM1-2.5, but no with PM1. The results showed that increase of hsCRP, sTNF-RII, and vWF were not significantly associated with any of the PM sizes investigated in the healthy young subjects. Our results provided some evidence that short-term exposure to PM10, PM2.5-10, PM2.5, PM1-2.5, and PM1was associated with inflammation and coagulation blood markers, but associations were depended on PM size and also differed across the various time lag. © 2017 Elsevier Ltd