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Polyethylenimine-Graft-Poly (Maleic Anhydride-Alt-1-Octadecene) Coated Fe3o4 Magnetic Nanoparticles: Promising Targeted Ph-Sensitive System for Curcumin Delivery and Mr Imaging Publisher



Molaei H1 ; Zaaeri F2 ; Sharifi S3 ; Ramazani A1 ; Safaei S4 ; Abdolmohammadi J5 ; Khoobi M6
Authors

Source: International Journal of Polymeric Materials and Polymeric Biomaterials Published:2021


Abstract

A theranostic amphiphilic nanocarrier based on iron oxide core with polyethyleneimine and poly(maleic anhydride-alt-1-octadecene) shell was synthesized, labeled with folic acid and loaded with Curcumin. Fe3O4@PIMF nanoparticles displayed a size of 20–30 nm with a shell thickness of 2–5 nm. Fe3O4@PIMF-CUR MNPs exhibited pH-responsive release behavior matched with Michaelis–Menten model. The MNPs showed more toxicity than free CUR against MCF-7 and Hela cells, while the drug-free carrier was safe against both cell lines. Hemolytic activity less than 1.5% in concentrations of <500 µg/mL indicated excellent blood compatibility. Appropriate negative signal enhancement in MRI confirmed the efficiency of the system for cancer theranostics. © 2020 Taylor & Francis Group, LLC.
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