Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Green Decarboxylative Aminoalkylation of Coumarin-3-Carboxylic Acids Publisher



Soltani SS1 ; Golshani M2 ; Moghimi S2 ; Farnia SMF1 ; Ketabforoosh SHME3 ; Akbarzadeh T4 ; Foroumadi A2, 4
Authors

Source: ChemistrySelect Published:2019


Abstract

A new metal-free decarboxylative coupling reaction between coumarin-3-carboxylic acid derivatives, formaldehyde, and amines is developed. The use of water as the solvent without using any catalyst or additive, excellent functional group tolerance, and good yields are the beneficial features of this synthetic pathway. The cholinesterase inhibitory activity of some selected target compounds is also evaluated. © 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
Other Related Docs