Harnessing the Fundamental Roles of Vitamins: The Potent Anti-Oxidants in Longevity Publisher Pubmed



Izadi M^{1, 2, 3} ; Sadri N^{2, 3, 4} ; Abdi A^{2, 3, 5} ; Raeis Zadeh MM^{2, 3, 5} ; Sadatipour S^{2, 3, 6} ; Baghdadi G^{2, 3, 7} ; Jalaei D^{2, 3, 8} ; Tahmasebi S^{2, 3, 9}
Source: Biogerontology Published:2025

Abstract

Aging is a complex and heterogeneous biological process characterized by telomere attrition, genomic instability, mitochondrial dysfunction, and disruption in nutrient sensing. Besides contributing to the progression of cancer, metabolic disorders, and neurodegenerative diseases, these manifestations of aging also adversely affect organ function. It is crucial to understand these mechanisms and identify interventions to modulate them to promote healthy aging and prevent age-related diseases. Vitamins have emerged as potential modulators of aging beyond their traditional roles in health maintenance. There is an increasing body of evidence that hormetic effects of vitamins are responsible for activating cellular stress responses, repair mechanisms, and homeostatic processes when mild stress is induced by certain vitamins. It is evident from this dual role that vitamins play a significant role in preventing frailty, promoting resilience, and mitigating age-related cellular damage. Moreover, addressing vitamin deficiencies in the elderly could have a significant impact on slowing aging and extending life expectancy. A review of recent advances in the role of vitamins in delaying aging processes and promoting multiorgan health is presented in this article. The purpose of this paper is to provide a comprehensive framework for using vitamins as strategic tools for fostering longevity and vitality. It offers a fresh perspective on vitamins’ role in aging research by bridging biological mechanisms and clinical opportunities. © The Author(s), under exclusive licence to Springer Nature B.V. 2025.