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A Novel Way for Detection of Antiparkinsonism Drug Entacapone Via Electrodeposition of Silver Nanoparticles/Functionalized Multi-Walled Carbon Nanotubes As an Amperometric Sensor Publisher Pubmed



Baghayeri M1 ; Tehrani MB2 ; Amiri A1 ; Maleki B1 ; Farhadi S1
Authors

Source: Materials Science and Engineering C Published:2016


Abstract

Silver (Ag) nanoparticles were electrochemically deposited on the film of a metformin functionalized multi-walled carbon nanotube modified glassy carbon electrode (Met-MWCNT/GCE), which fabricated an Ag@Met-MWCNT nanocomposite sensor (Ag@Met-MWCNT/GCE) to detect entacapone (ENT). The Ag@Met-MWCNT nanocomposite was characterized by field emission scanning electrochemical microscopy (FESEM), X-ray diffraction (XRD) analysis, FT-IR and electrochemical tests. The modified electrode showed a large electrocatalytic activity for reduction of ENT. This improved activity indicates that Met@MWCNT plays a crucial role in the dispersion and stabilization of Ag nanoparticles on GCE. Under the optimized conditions the linear range for the detection of the ENT was obtained to be 0.05 to 70.0 μM with a low detection limit of 15.3 nM. The proposed sensor can effectively analyse ENT concentration in pharmaceutical formulations and human urine samples, avoiding interference, and is a promising ENT sensor due to good sensitivity, stability and low cost. © 2016 Elsevier B.V. All rights reserved.
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