Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Anderson-Type Manganese Polyoxomolybdate Hybrid Nanocomposite for Boosting Drug Delivery Against Breast Cancer Publisher



Mahvash S1 ; Zavareh VA2 ; Taymouri S3 ; Mirian M4 ; Ramezanialiakbari M5 ; Dousti F6 ; Rostami M7
Authors

Source: Journal of Drug Delivery Science and Technology Published:2023


Abstract

Novel biocompatible nanocomposites (NCs) of Anderson-type manganese polyoxomolybdate (MnMo6) in chitosan imidazolium platform (MnMo6@CSIm NCs) were introduced for modulating cytotoxicity profile. The anticancer activity of optimized NCs was evaluated against breast cancer cell lines (MCF-7 & MDA-MB-231) and HUVEC normal cells using the MTT assay. Cellular uptake, apoptosis ratio, and cell migration inhibition were also evaluated on the MDA-MB-231 cell line. The optimized pH-responsive NCs had better anticancer activity than free MnMo6 without cytotoxicity against normal HUVEC cells. The cellular uptake was about 100%, and the apoptosis value was higher (81%) than free MnMo6. Interestingly, the MnMo6@CSIm NCs inhibited the cell migration 1.5 times better than the free MnMo6. These results are fascinating to follow more pre-clinical studies. © 2023 Elsevier B.V.
Related Docs
View other Related Docs
1. Ph-Responsive Glucosamine Anchored Polydopamine Coated Mesoporous Silica Nanoparticles for Delivery of Anderson-Type Polyoxomolybdate in Breast Cancer, Journal of Microencapsulation (2022)
2. Using Chitosan-Stabilized, Hyaluronic Acid-Modified Selenium Nanoparticles to Deliver Cd44-Targeted Plk1 Sirnas for Treating Bladder Cancer, Nanomedicine (2023)
3. Mnfe2o4@L-Cysteine As a Drug Delivery System, in Vitro Cytotoxicity Evaluation on Human Breast Cancer Cell (Mcf7) and Dft Calculation, ChemistrySelect (2025)
Experts (# of related papers)
View all Related Experts
Mehdi Shafee Ardestani (2)
Seyed Nasser Ostad (2)
Other Related Docs
4. Chlorambucil-Chitosan Nano-Conjugate: An Efficient Agent Against Breast Cancer Targeted Therapy, Current Drug Delivery (2021)
5. Application of New Zno Nanoformulation and Ag/Fe/Zno Nanocomposites As Water-Based Nanofluids to Consider in Vitro Cytotoxic Effects Against Mcf-7 Breast Cancer Cells, Artificial Cells# Nanomedicine and Biotechnology (2017)
6. Exploring the Potential of Montmorillonite As an Antiproliferative Nanoagent Against Mda-Mb-231 and Mcf-7 Human Breast Cancer Cells, Cells (2024)
7. Aptamer-Functionalized Chitosan-Coated Gold Nanoparticle Complex As a Suitable Targeted Drug Carrier for Improved Breast Cancer Treatment, Nanotechnology Reviews (2022)
8. Anti-Muc1 Nanobody Conjugated by Chitosan Nanoparticle With Enhancement of Anti-Proliferation Activity in Breast Cancer Cell Lines, Chemical Papers (2023)
9. New Salen-Type Manganese(Iii) Schiff Base Complexes Derived From Meso -1,2-Diphenyl-1,2-Ethylenediamine: In Vitro Anticancer Activity, Mechanism of Action, and Molecular Docking Studies, Journal of Coordination Chemistry (2015)
10. Β-Cyclodextrin Functionalized Poly (5-Amidoisophthalicacid) Grafted Fe3o4 Magnetic Nanoparticles: A Novel Biocompatible Nanocomposite for Targeted Docetaxel Delivery, Journal of Magnetism and Magnetic Materials (2016)
11. Fabrication of Poly(Ε-Caprolactone)/Paclitaxel (Core)/Chitosan/Zein/Multi-Walled Carbon Nanotubes/Doxorubicin (Shell) Nanofibers Against Mcf-7 Breast Cancer, Polymers for Advanced Technologies (2023)
12. Design of Chiral 2-Oxazoline-Based Amino Acid Bioconjugates As Anticancer Agents: Synthesis, in Vitro Anticancer Activity, Admet Prediction With Molecular Docking and Molecular Dynamic Simulation Insights, Archives of Biochemistry and Biophysics (2025)
13. Synthesis and Characterization of Chrysin-Loaded Pcl-Peg-Pcl Nanoparticle and Its Effect on Breast Cancer Cell Line, Biomedicine and Pharmacotherapy (2016)
14. Multimodal Chitosan-Based Materials for Combination Immunotherapy in Cancers: Structural Engineering, Immune Regulatory Mechanisms and Synergistic Therapeutic Applications, Carbohydrate Polymers (2025)
15. Pi3k/Akt Inhibition and Down-Regulation of Bcrp Re-Sensitize Mcf7 Breast Cancer Cell Line to Mitoxantrone Chemotherapy, Iranian Journal of Basic Medical Sciences (2015)
16. Apoptotic Effects of Mucin1 Aptamer-Conjugated Nanoparticles Containing Docetaxel and C-Met Sirna on Skbr3 Human Metastatic Breast Cancer Cells, Jundishapur Journal of Natural Pharmaceutical Products (2019)
17. Chitosan/Agarose-Encapsulated Oleic Acid-Coated Magnetite Nanoparticles As a Chemotherapeutic-Loaded Scaffold for Drug Delivery: Physico-Chemical and in Vitro Biological Characteristics, International Journal of Biological Macromolecules (2025)
18. Effects of 8-Hydroxyquinoline-Coated Graphene Oxide on Cell Death and Apoptosis in Mcf-7 and Mcf-10 Breast Cell Lines, Iranian Journal of Basic Medical Sciences (2020)
19. Using Chitosan-Coated Magnetite Nanoparticles As a Drug Carrier for Opioid Delivery Against Breast Cancer, Pharmaceutical Development and Technology (2024)
20. Super Magnetic Niosomal Nanocarrier As a New Approach for Treatment of Breast Cancer: A Case Study on Sk-Br-3 and Mda-Mb-231 Cell Lines, International Journal of Molecular Sciences (2021)