Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
The First Experience of Sequential Liver-Kidney Transplantation for the Treatment of Primary Hyperoxaluria Type-1 in Iran As a Developing Country Publisher Pubmed



Naderi G1, 2 ; Tabassomi F1, 2 ; Latif A1, 2 ; Ganji M1, 2
Authors

Source: Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation# Saudi Arabia Published:2016


Abstract

Primary hyperoxaluria Type-1 (PH-1) is caused by a deficiency of alanine-glyoxylate aminotransferase manifesting as urolithiasis, nephrocalcinosis, and end-stage renal disease (ESRD). Among treatment options, best outcomes have been achieved by sequential liver-kidney transplantation (Seq-LKT). Herein, we report a patient with PH-1 and ESRD who underwent Seq-LKT in Iran. Criteria for diagnosis included a history of recurring calcium oxalate renal stones and elevated urine oxalate level combined with liver biopsy and absent enzymatic activity at the age of 13 years. Conservative treatment including pyridoxine, potassium citrate solution, high fluid intake, and hemodialysis was administered initially. Liver transplantation was performed at the age of 17 years from a deceased donor followed 4½ months later by a living-unrelated donor kidney transplantation. After two years of follow-up, the patient experienced no complications and had normal liver and renal function. This is the first successful experience of Seq-LKT in the treatment of PH-1 in Iran as a developing country with limited access to equipment and medications.
Other Related Docs
8. Slc34a3 Intronic Deletion in an Iranian Kindred With Hereditary Hypophosphatemic Rickets With Hypercalciuria, JCRPE Journal of Clinical Research in Pediatric Endocrinology (2018)
17. Early Postkidney Transplantation Hypophosphatemia, Journal of Research in Medical Sciences (2020)