Phthalimides: Developments in Synthesis and Functionalization Publisher

Summary: Why are phthalimides key in medicine? A study reviews how these compounds are synthesized for use in drugs and other fields, advancing pharmaceutical development. #Pharmaceuticals #Chemistry

Doraghi F¹ ; Morshedsolouk MH^{1, 2} ; Zahedi NA³ ; Larijani B¹ ; Mahdavi M¹
Source: RSC Advances Published:2024

Abstract

Phthalimides, an important class of biologically active N-heterocycles, are not only found in pharmaceuticals, natural products, agrochemicals, polymers, and dyes, but also serve as building blocks in organic transformations. Many synthetic methods, including metal catalysis and metal-free systems, have been developed to prepare functionalized phthalimides. In this review, we describe the developments in the synthesis and functionalization of phthalimides over the past two decades. © 2024 The Royal Society of Chemistry.