Bone Mineral Density and Muscle Mass in Adults With Developmental Skeletal Discrepancies Publisher Pubmed



Sharifi R¹ ; Kordi S² ; Noravesh F³ ; Aghababaei Y⁴ ; Ramezani M⁵ ; Maghbooli Z⁶
Source: BMC Musculoskeletal Disorders Published:2022

Abstract

Background: It was aimed to investigate the musculoskeletal status in individuals diagnosed with skeletal discrepancies. Methods: This case–control study was performed on 35 patients with developmental skeletal discrepancies listed for orthognathic surgery as a case group and 33 patients who were nominated for wisdom tooth removal as a control group. All participants were aged 18–40 years and the research was carried out in the period between May 2018 and May 2019. Dual X-ray absorptiometry (DEXA) was used to assess bone mass density at three bone sites: total hip, femoral neck, and the spinal lumbar vertebrae (L1-L4). The appendicular muscle mass index (ASMI) was measured based on the four limbs from the DEXA scan. Results: Our data showed that 45.7% (16) of the case group were osteopenic or osteoporotic while in the control group only 21.2% (7) were osteopenic in at least one region (total hip, femoral neck, or lumbar) (p-value = 0.03). Regarding muscle mass, there was significantly lower SMI in subjects with skeletal discrepancies (case group) compared with the control group (median (IQR) 5.9 (2.5) vs. 6.8 (2.9) (kg/m2), respectively, p = 0.04). Conclusions: There is an essential need for more studies to understand the exact interrelationship between musculoskeletal status and skeletal jaw discrepancies. © 2022, The Author(s).