Lessons Learned: Quality Analysis of Optical Coherence Tomography in Neuromyelitis Optica

Lessons Learned: Quality Analysis of Optical Coherence Tomography in Neuromyelitis Optica Publisher Pubmed

Salih H ; Samadzadeh S ; Bereuter C ; Motamedi S ; Chien C ; Villoslada P ; Stiebelkalish H ; Asgari N ; Maodraayer Y ; Ringelstein M ; Havla J ; Peixoto MAL ; Kim HJ ; Palace J Show All Authors

Salih H
Samadzadeh S
Bereuter C
Motamedi S
Chien C
Villoslada P
Stiebelkalish H
Asgari N
Maodraayer Y
Ringelstein M
Havla J
Peixoto MAL
Kim HJ
Palace J
Leite MI
Sharma SM
Ashtari F
Kafieh R
Pandit L
Aktas O
Albrecht P
Leocani L
Lotan I
Siritho S
De Seze J
Marignier R
Tilikete CF
Bichuetti DB
Tavares IM
Altintas A
Jacob A
Huda S
De Castillo IS
Cook LJ
Yeaman MR
Petzold A
Brandt AU
Paul F
Oertel FC
Zimmermann HG

Source: Annals of Clinical and Translational Neurology Published:2026

Abstract

Introduction: Optical coherence tomography (OCT)-derived retina measurements are markers for neuroaxonal visual pathway status. High-quality OCT scans are essential for reliable measurements, but their acquisition is particularly challenging in eyes with severe visual impairment, as often observed in neuromyelitis optica spectrum disorders (NMOSD). Objective: To investigate OCT quality issues in real-world data from the international Collaborative Retrospective Study on Retinal OCT in Neuromyelitis Optica (CROCTINO). Methods: We evaluated the quality of peripapillary and macular OCT scans, using Heidelberg Spectralis SD-OCT, Carl Zeiss Cirrus HD-OCT, or Topcon SD-OCT across 22 centers. Experienced graders applied OSCAR-IB criteria for OCT quality. Eyes were classified as severely visually impaired or not based on a 1.0 logMAR cut-off. Quality outcomes were compared using the Chi-square test. Results: A total of 3075 OCT scans (1630 peripapillary, 1445 macular) from 539 people with NMOSD and related conditions were evaluated. Macular scans were rejected more often than peripapillary scans due to quality issues (20.1% vs. 14.5%, p < 0.001). Rejection rates were higher in eyes with severe visual impairment (peripapillary: 28.9%, macular: 41.6%) compared to eyes without severe visual impairment (peripapillary: 10.7%, p < 0.001; macular: 14.6%, p < 0.001). Conclusion: Our study revealed that approximately one in six scans was rejected due to low quality, with higher rejection rates in eyes with severe visual impairment. As scan quality can bias quantitative outcomes and artificial intelligence applications, these findings emphasize the unmet need for standardized OCT practices tailored to NMOSD and other conditions involving severe visual impairment. © 2025 The Author(s). Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.

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Style	Citing Format
MLA	Salih H, et al.. "Lessons Learned: Quality Analysis of Optical Coherence Tomography in Neuromyelitis Optica." Annals of Clinical and Translational Neurology, vol. 13, no. 3, 2026, pp. 581-592.
APA	Salih H, Samadzadeh S, Bereuter C, Motamedi S, Chien C, Villoslada P, Stiebelkalish H, Asgari N, Maodraayer Y, Ringelstein M, Havla J, Peixoto MAL, Kim HJ, Palace J, Leite MI, Sharma SM, Ashtari F, Kafieh R, Pandit L, ... Zimmermann HG (2026). Lessons Learned: Quality Analysis of Optical Coherence Tomography in Neuromyelitis Optica. Annals of Clinical and Translational Neurology, 13(3), 581-592.
Chicago	Salih H, Samadzadeh S, Bereuter C, Motamedi S, Chien C, Villoslada P, Stiebelkalish H, et al.. "Lessons Learned: Quality Analysis of Optical Coherence Tomography in Neuromyelitis Optica." Annals of Clinical and Translational Neurology 13, no. 3 (2026): 581-592.
Harvard	Salih H et al. (2026) 'Lessons Learned: Quality Analysis of Optical Coherence Tomography in Neuromyelitis Optica', Annals of Clinical and Translational Neurology, 13(3), pp. 581-592.
Vancouver	Salih H, Samadzadeh S, Bereuter C, Motamedi S, Chien C, Villoslada P, et al.. Lessons Learned: Quality Analysis of Optical Coherence Tomography in Neuromyelitis Optica. Annals of Clinical and Translational Neurology. 2026;13(3):581-592.
BibTex	@article{ author = {Salih H and Samadzadeh S and Bereuter C and Motamedi S and Chien C and Villoslada P and Stiebelkalish H and Asgari N and Maodraayer Y and Ringelstein M and Havla J and Peixoto MAL and Kim HJ and Palace J and Leite MI and Sharma SM and Ashtari F and Kafieh R and Pandit L and Aktas O and Albrecht P and Leocani L and Lotan I and Siritho S and De Seze J and Marignier R and Tilikete CF and Bichuetti DB and Tavares IM and Altintas A and Jacob A and Huda S and De Castillo IS and Cook LJ and Yeaman MR and Petzold A and Brandt AU and Paul F and Oertel FC and Zimmermann HG}, title = {Lessons Learned: Quality Analysis of Optical Coherence Tomography in Neuromyelitis Optica}, journal = {Annals of Clinical and Translational Neurology}, volume = {13}, number = {3}, pages = {581-592}, year = {2026} }
RIS	TY - JOUR AU - Salih H AU - Samadzadeh S AU - Bereuter C AU - Motamedi S AU - Chien C AU - Villoslada P AU - Stiebelkalish H AU - Asgari N AU - Maodraayer Y AU - Ringelstein M AU - Havla J AU - Peixoto MAL AU - Kim HJ AU - Palace J AU - Leite MI AU - Sharma SM AU - Ashtari F AU - Kafieh R AU - Pandit L AU - Aktas O AU - Albrecht P AU - Leocani L AU - Lotan I AU - Siritho S AU - De Seze J AU - Marignier R AU - Tilikete CF AU - Bichuetti DB AU - Tavares IM AU - Altintas A AU - Jacob A AU - Huda S AU - De Castillo IS AU - Cook LJ AU - Yeaman MR AU - Petzold A AU - Brandt AU AU - Paul F AU - Oertel FC AU - Zimmermann HG TI - Lessons Learned: Quality Analysis of Optical Coherence Tomography in Neuromyelitis Optica JO - Annals of Clinical and Translational Neurology VL - 13 IS - 3 SP - 581 EP - 592 PY - 2026 ER -

Style

Citing Format

MLA

Salih H, et al.. "Lessons Learned: Quality Analysis of Optical Coherence Tomography in Neuromyelitis Optica." Annals of Clinical and Translational Neurology, vol. 13, no. 3, 2026, pp. 581-592.

APA

Salih H, Samadzadeh S, Bereuter C, Motamedi S, Chien C, Villoslada P, Stiebelkalish H, Asgari N, Maodraayer Y, Ringelstein M, Havla J, Peixoto MAL, Kim HJ, Palace J, Leite MI, Sharma SM, Ashtari F, Kafieh R, Pandit L, ... Zimmermann HG (2026). Lessons Learned: Quality Analysis of Optical Coherence Tomography in Neuromyelitis Optica. Annals of Clinical and Translational Neurology, 13(3), 581-592.

Chicago

Salih H, Samadzadeh S, Bereuter C, Motamedi S, Chien C, Villoslada P, Stiebelkalish H, et al.. "Lessons Learned: Quality Analysis of Optical Coherence Tomography in Neuromyelitis Optica." Annals of Clinical and Translational Neurology 13, no. 3 (2026): 581-592.

Harvard

Salih H et al. (2026) 'Lessons Learned: Quality Analysis of Optical Coherence Tomography in Neuromyelitis Optica', Annals of Clinical and Translational Neurology, 13(3), pp. 581-592.

Vancouver

Salih H, Samadzadeh S, Bereuter C, Motamedi S, Chien C, Villoslada P, et al.. Lessons Learned: Quality Analysis of Optical Coherence Tomography in Neuromyelitis Optica. Annals of Clinical and Translational Neurology. 2026;13(3):581-592.

BibTex

@article{ author = {Salih H and Samadzadeh S and Bereuter C and Motamedi S and Chien C and Villoslada P and Stiebelkalish H and Asgari N and Maodraayer Y and Ringelstein M and Havla J and Peixoto MAL and Kim HJ and Palace J and Leite MI and Sharma SM and Ashtari F and Kafieh R and Pandit L and Aktas O and Albrecht P and Leocani L and Lotan I and Siritho S and De Seze J and Marignier R and Tilikete CF and Bichuetti DB and Tavares IM and Altintas A and Jacob A and Huda S and De Castillo IS and Cook LJ and Yeaman MR and Petzold A and Brandt AU and Paul F and Oertel FC and Zimmermann HG}, title = {Lessons Learned: Quality Analysis of Optical Coherence Tomography in Neuromyelitis Optica}, journal = {Annals of Clinical and Translational Neurology}, volume = {13}, number = {3}, pages = {581-592}, year = {2026} }

RIS

TY - JOUR
AU - Salih H
AU - Samadzadeh S
AU - Bereuter C
AU - Motamedi S
AU - Chien C
AU - Villoslada P
AU - Stiebelkalish H
AU - Asgari N
AU - Maodraayer Y
AU - Ringelstein M
AU - Havla J
AU - Peixoto MAL
AU - Kim HJ
AU - Palace J
AU - Leite MI
AU - Sharma SM
AU - Ashtari F
AU - Kafieh R
AU - Pandit L
AU - Aktas O
AU - Albrecht P
AU - Leocani L
AU - Lotan I
AU - Siritho S
AU - De Seze J
AU - Marignier R
AU - Tilikete CF
AU - Bichuetti DB
AU - Tavares IM
AU - Altintas A
AU - Jacob A
AU - Huda S
AU - De Castillo IS
AU - Cook LJ
AU - Yeaman MR
AU - Petzold A
AU - Brandt AU
AU - Paul F
AU - Oertel FC
AU - Zimmermann HG
TI - Lessons Learned: Quality Analysis of Optical Coherence Tomography in Neuromyelitis Optica
JO - Annals of Clinical and Translational Neurology
VL - 13
IS - 3
SP - 581
EP - 592
PY - 2026
ER -

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