Incidence and Clinical Characteristics of Amyotrophic Lateral Sclerosis During the Post-Covid-19 Period: A Population-Based Study From Isfahan, Iran Publisher Pubmed

Summary: Did COVID-19 change ALS patterns? A retrospective study in Isfahan identified 63 new cases and suggested a possible infection link, but could not establish causality. #ALS #COVID19

Etemadifar M ; Salari M ; Kashefi M ; Shams Y ; Heydari Sichani M ; Hojjatipour F
Source: Neurodegenerative Disease Management Published:2026

Abstract

Aims: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder. Understanding the underlying causes would help further studies on the pathogenesis and treatments. Recent interest has emerged in evaluating whether the COVID-19 pandemic and vaccination have any influence on the epidemiological patterns of ALS. Materials & methods: To assess this association in Isfahan, Iran, during the post-COVID-19 era, we conducted this retrospective study. Newly diagnosed ALS cases were identified, and demographic data, environmental exposures, comorbidities, vaccination history, and other aspects were collected. Results: A total of 63 patients were diagnosed with definite ALS, yielding an incidence rate of 0.74 per 100,000 person-years (95% CI: 0.57–0.94). The mean age was 59.7 ± 11.6 years, and cases were predominantly male (73%). Of the 63 new ALS-diagnosed cases, 45% of patients reported probable prior COVID-19 infection, and 95.3% mentioned at least one dose of COVID-19 vaccination. Bulbar signs, including facial muscle weakness, tongue atrophy, and fasciculation, were present in 46% of cases, and emotional lability and cognitive decline were observed in 20.6%. Conclusion: We showed a probable relation between COVID-19 infection and the epidemiology of ALS in post-COVID era. However, our results and symptom alterations require further investigation. © 2026 Informa UK Limited, trading as Taylor & Francis Group.