Relationship Between Protamine Deficiency With Fertilization Rate and Incidence of Sperm Premature Chromosomal Condensation Post-Icsi

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):

Share By

Relationship Between Protamine Deficiency With Fertilization Rate and Incidence of Sperm Premature Chromosomal Condensation Post-Icsi Publisher Pubmed

Nasresfahani MH^{1, 2, 3} ; Razavi S³ ; Mozdarani H^{1, 4} ; Mardani M³ ; Azvagi H³

Source: Andrologia Published:2004

Abstract

After aneuploidy, sperm premature chromatin condensation (PCC) is the next prevalent cause of fertilization failure. Therefore the aim of this study was to evaluate the effect of sperm protamine deficiency on sperm PCC formation post-ICSI. Chromatin analysis was carried out on failed fertilized oocytes post-ICSI and incidences of sperm PCC were evaluated and the results were compared with the extent of protamine deficiency assessed by chromomycin A3.The results show that incidence of sperm PCC was significantly different in failed fertilized oocytes injected from semen samples with greater or less than 30% CMA3 positivity (P = 0.04). However, except for fertilization rate (P < 0.001), the mean number of MII, MI and germinal vesicles oocytes and percentage normal sperm were not significantly different between the two groups (P > 0.05). A significant correlation was observed between sperm protamine deficiency with fertilization rate. Hence sperm protamine deficiency affects fertilization rate and possibly prones sperm to PCC post-ICSI.

Related Docs

View other Related Docs

1. Can Sperm Protamine Deficiency Induce Sperm Premature Chromosomal Condensation?, Andrologia (2006)

2. Effect of Human Sperm Chromatin Anomalies on Fertilization Outcome Post-Icsi, Andrologia (2003)

3. Effects of Failed Oocyte Activation and Sperm Protamine Deficiency on Fertilization Post-Icsi, Reproductive BioMedicine Online (2007)

Experts (# of related papers)

View all Related Experts

Shahnaz Razavi (20)

Mohammad Mardani (11)

Other Related Docs

4. The Role of Sperm Chromatin Anomalies on the Outcome of Assisted Reproductive Techniques, Yakhteh (2006)

5. Effect of Protamine-2 Deficiency on Icsi Outcome, Reproductive BioMedicine Online (2004)

6. Efficiency of Sil-Select and Percoll to Recover Spermatozoa With Normal Chromatin and Morphology and the Effect of These Parameters on Fertilization, Embryo Quality and Cleavage Score, Middle East Fertility Society Journal (2003)

7. Credibility of Chromomycin A3 Staining in Prediction of Fertility, International Journal of Fertility and Sterility (2009)

8. Failed Fertilization After Icsi and Spermiogenic Defects, Fertility and Sterility (2008)

9. Relation Between Different Human Sperm Nuclear Maturity Tests and in Vitro Fertilization, Journal of Assisted Reproduction and Genetics (2001)

10. Effect of Varicocelectomy on Semen Parameters and Protamine Deficiency 3 and 6 Months Post Surgery, Journal of Isfahan Medical School (2007)

11. Varicocelectomy: Semen Parameters and Protamine Deficiency, International Journal of Andrology (2009)

12. Evaluation of Sperm Selection Procedure Based on Hyaluronic Acid Binding Ability on Icsi Outcome, Journal of Assisted Reproduction and Genetics (2008)

13. Effect of Varicocelectomy on Semen Parameters and Sperm Chromatin Status, Yakhteh (2005)

14. Effect of Sperm Dna Damage and Sperm Protamine Deficiency on Fertilization and Embryo Development Post-Icsi, Reproductive BioMedicine Online (2005)

15. Can Zeta Sperm Selection Method, Recover Sperm With Higher Dna Integrity Compare to Density Gradient Centrifugation?, Iranian Journal of Reproductive Medicine (2009)

16. The Comparison of Efficiency of Density Gradient Centrifugation and Zeta Methods in Separation of Mature Sperm With Normal Chromatin Structure, Yakhteh (2009)

17. Evaluation of Zeta and Ha-Binding Methods for Selection of Spermatozoa With Normal Morphology, Protamine Content and Dna Integrity, Andrologia (2010)

18. Influence of Sperm Chromatin Anomalies on Assisted Reproductive Technology Outcome, Fertility and Sterility (2009)

19. Selection of Sperm Based on Combined Density Gradient and Zeta Method May Improve Icsi Outcome, Human Reproduction (2009)

20. Artificial Oocyte Activation in Severe Teratozoospermia Undergoing Intracytoplasmic Sperm Injection, Fertility and Sterility (2008)

Style	Citing Format
MLA	Nasresfahani MH, et al.. "Relationship Between Protamine Deficiency With Fertilization Rate and Incidence of Sperm Premature Chromosomal Condensation Post-Icsi." Andrologia, vol. 36, no. 3, 2004, pp. 95-100.
APA	Nasresfahani MH, Razavi S, Mozdarani H, Mardani M, Azvagi H (2004). Relationship Between Protamine Deficiency With Fertilization Rate and Incidence of Sperm Premature Chromosomal Condensation Post-Icsi. Andrologia, 36(3), 95-100.
Chicago	Nasresfahani MH, Razavi S, Mozdarani H, Mardani M, Azvagi H. "Relationship Between Protamine Deficiency With Fertilization Rate and Incidence of Sperm Premature Chromosomal Condensation Post-Icsi." Andrologia 36, no. 3 (2004): 95-100.
Harvard	Nasresfahani MH et al. (2004) 'Relationship Between Protamine Deficiency With Fertilization Rate and Incidence of Sperm Premature Chromosomal Condensation Post-Icsi', Andrologia, 36(3), pp. 95-100.
Vancouver	Nasresfahani MH, Razavi S, Mozdarani H, Mardani M, Azvagi H. Relationship Between Protamine Deficiency With Fertilization Rate and Incidence of Sperm Premature Chromosomal Condensation Post-Icsi. Andrologia. 2004;36(3):95-100.
BibTex	@article{ author = {Nasresfahani MH and Razavi S and Mozdarani H and Mardani M and Azvagi H}, title = {Relationship Between Protamine Deficiency With Fertilization Rate and Incidence of Sperm Premature Chromosomal Condensation Post-Icsi}, journal = {Andrologia}, volume = {36}, number = {3}, pages = {95-100}, year = {2004} }
RIS	TY - JOUR AU - Nasresfahani MH AU - Razavi S AU - Mozdarani H AU - Mardani M AU - Azvagi H TI - Relationship Between Protamine Deficiency With Fertilization Rate and Incidence of Sperm Premature Chromosomal Condensation Post-Icsi JO - Andrologia VL - 36 IS - 3 SP - 95 EP - 100 PY - 2004 ER -

Science Communicator Platform

Authors

Abstract